Supplemental breast cancer screening is a very timely topic that every radiologist should know about. In this episode, based on my Radiology Review Insider article of the same name available at theradiologyreview.com, I provide an overview of the current supplemental screening landscape. In this episode I highlight current and future technologies for supplemental screening including advanced imaging (contrast-enhanced mammography, molecular breast imaging, breast MRI, breast CT, whole breast ultrasound, elastogrpahy, contrast-enhanced breast ultrasound), artificial intelligence, and ctDNA assays.  I also share my thoughts on current challenges and opportunities pertaining to supplemental breast cancer screening. All content of this podcast episode is my opinion only, and is presented to foster interest and further learning on this important and timely topic. Prepare to succeed!