starring Cattle baron and town namesake George Washington "G.W." McLintock lives as a bachelor on his ranch. His wife, "Kate", abandoned him with no explanation and become a socialite back East two years prior; his daughter, "Becky", is away finishing her college degree. In the town, G.W. is disliked by bureaucrat Matt Douglas and Governor Cuthbert H. Humphrey. However, he is a friend to many, including Sheriff Lord, General Store owner Jake Birnbaum, and the local beggars and Comanche Indians.

• John Wayne as George Washington "G.W." McLintock
• Maureen O'Hara as Katherine "Kate" McLintock
• Patrick Wayne as Devlin "Dev" Warren
• Stefanie Powers as Rebecca "Becky" McLintock
• Jack Kruschen as Jake Birnbaum