In this episode I was joined by Dr. David Gorski, managing editor and prolific writer at the thoroughly indispensable website, Science-Based Medicine. Dr. Gorski earned his MD at the University of Michigan and a PhD in cellular physiology at Case Western Reserve University. He is both a professor of surgery at Wayne State University as well as a surgical oncologist at the Barbara Ann Karmanos Cancer Institute where he specialises in breast cancer surgery. Near the beginning of our conversation, I asked Dr. Gorski for his view on the scientific method and how skepticism is one of its central characteristics. My guest explained how science-based medicine is related to, but still in important respects distinct from, evidence-based medicine, which is itself a fairly new approach dating back only a few decades. We discussed an excellent essay from earlier this year in which he argued that all examples of science denial are essentially a form of conspiracy thinking. While his argument is largely persuasive, I ventured to propose a yet deeper analytical layer involving the high degree of religiosity in American society, as compared to other developed nations, that serves as another crucial driver for the pervasive conspiratorial ideation so prevalent in the United States. We then spoke about the highly frustrating asymmetry between those trying to assiduously gather reliable information and rectify inaccuracies and those who effortlessly churn out misleading and false claims. Dr. Gorski mentioned Brandolini’s Law, which states that it takes an order of magnitude more to refute bullshit than it does to create bullshit, that perfectly summarise this dilemma, and one the Covid pandemic has brought into horribly stark relief. I asked him about his first forays into skepticism in the late 1990s when he grappled with Holocaust deniers, before moving onto discussing fallacious ideas about Covid-19, the anti-vaccine movement, the breakthrough new MRNA technology used in some Covid vaccines, the efficacy of vaccines developed against the virus, and the often unethical behaviour of pharmaceutical companies witnessed during this unprecedented global pandemic. We also spoke about how the Republican Party has become the party of choice for anti-vaxxers, some prominent figures in this movement, including Mike Adams of Natural News infamy and Joseph Mercola, what might motivate these players, and ways to counter the tidal wave of irrationality, idiocy, disinformation, and propaganda to which we are incessantly subjected, particularly on social media. In light of this seemingly inexorable multi-pronged tsunami of lunacy, I averred that we sadly appear to live in an age of Endarkment, rather than one of Enlightenment. Science-Based Medicine: https://sciencebasedmedicine.org/ Dr Gorski’s essay, ‘All science denial is a form of conspiracy theory’: https://sciencebasedmedicine.org/all-science-denial-is-a-form-of-conspiracy-theory/ Dr. Gorski’s Respectful Insolence blog: https://respectfulinsolence.com/ Dr. Gorski’s Twitter account: @gorskon Twitter account for Skeptically Curious: https://twitter.com/SkepticallyCur1 Patreon page for Skeptically Curious: https://www.patreon.com/skepticallycurious