Natasha Wanganeen is an Aboriginal actress. She is known for her starring role in the 2002 feature film Rabbit-Proof Fence, aged 15, and numerous television roles. Her debut film as co-writer and co-producer is the 2022 short film, an Indigenous sci-fi drama entitled Bunker: The Last Fleet, about an alien invasion of Australia, in which she also takes the lead role.

Natasha Wanganeen was born in Point Pearce, South Australia, moving to Port Adelaide when she was five years old.She  is a Ngarrindjeri, Narungga, Kaurna and Noongar woman.

Wanganeen starred in Rabbit-Proof Fence (released 2002), playing a dormitory boss at the age of fifteen, and the made-for-TV film Jessicadirected by Peter Andrikidis and released in 2004.

In 2017 she starred as a zombie-killer in the dystopian thriller Cargo. Also in 2017, she played the role of Gilyagan in Kate Grenville's play The Secret River presented during the Adelaide Festival in March, having previously played a different role in the 2015 two-part TV series of the same name.

In June 2020, Wanganeen was writing a script for her own independent film, Battle of the Ancestors, set 60,000 years ago against a backdrop of Aboriginal mythology, including Dreamtime stories and characters she knows from here childhood years. She is being supported by Screen Australiaand the South Australian Film Corporation in this endeavour, and is in talks with local production companies who are interested in seeing it made.

On the 10th of October 2023 Natasha appeared on the ABC TV show Q&A to debate the "Voice To Parliament" Referendum and was veery direct in her opposition to being recognised on the constitution.

Featuring music of Aunty Ruby Hunter: "Ngarrindjeri Woman"