Big Brains

University of Chicago Podcast Network

Translating groundbreaking research into digestible brain food. Big Brains, little bites. Produced by the University of Chicago Podcast Network & Winner of CASE "Grand Gold" award in 2022, Gold award in 2021, and named Adweek's "Best Branded Podcast" in 2020. read less

Our Editor's Take

The Big Brains podcast shares exciting discoveries from pioneering thinkers. Paul M. Rand leads communications for the University of Chicago and started the podcast in 2018. His mission was to share the many astounding ideas he saw on campus. New episodes drop weekly and are about half an hour long. It's a great way to receive quick and informative updates on exciting new research.

The podcast includes research on everything from gun violence to climate change. One episode investigates gut health with professors Cathryn Nagler and Eric Pamer. Cathryn is an immunologist, and Eric is a professor in the Department of Medicine. The two experts discuss the definition of good gut health and research on the function of the gut. They talk about the prevalence of food allergies, particularly for children. Plus, listeners learn about the impact of the pandemic on their research.

Professor Jonathan Lear joins another episode of the podcast to discuss the topic of grief. He's written a book entitled "Imagining the End: Mourning and Ethical Life." He talks to Paul about how and why mourning is vital to everyone's well-being. He also discusses the meaning of life and the value of gratitude.

In another episode, Professor Marc Schulz examines the secrets to a good life. He's a clinical psychologist and a professor of psychology. He has studied and written about happiness alongside psychiatrist Robert J Waldinger. Listeners can discover all about their fascinating study, which spanned 80 years. They share their innovative insights with stories from real-life people. The pair also discuss how strong relationships are crucial to happiness.

Big Brains is an insightful series of innovative thinking. Listeners will hear scholars from all fields sharing their research and remarkable discoveries. From the history of Black cinema to sleep, each episode brings new knowledge and perspective.

read less

ScienceScience

Start Here

How To Manifest Your Future Using Neuroscience, with James Doty

How To Manifest Your Future Using Neuroscience, with James Doty

We've all heard the phrase "Manifest Your Destiny" when it comes to wanting that new promotion, figuring out a new career path or just trying to achieve that long-term goal. It turns out that the act of manifestation is not merely pseudoscience—it actually has a body of research in neuroscience to back it up. Dr. James Doty has been exploring this topic throughout his career; and offers scientific research as well as tools on how to manifest your goals in his new book, Mind Magic: The Neuroscience of Manifestation and How It Changes Everything.James Doty is a clinical professor of neurosurgery at Stanford University, where is also the founder and director of the Center for Compassion and Altruism Research and Education. He explores how manifestation is not only a tool to achieve what we want, but it is also fundamentally about being selfless and caring for others in order to activate our deep internal happiness. Link to the advertised Chicago Booth Review Podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast24-202405/02

Episodes

How To Manifest Your Future Using Neuroscience, with James Doty

How To Manifest Your Future Using Neuroscience, with James Doty

We've all heard the phrase "Manifest Your Destiny" when it comes to wanting that new promotion, figuring out a new career path or just trying to achieve that long-term goal. It turns out that the act of manifestation is not merely pseudoscience—it actually has a body of research in neuroscience to back it up. Dr. James Doty has been exploring this topic throughout his career; and offers scientific research as well as tools on how to manifest your goals in his new book, Mind Magic: The Neuroscience of Manifestation and How It Changes Everything.James Doty is a clinical professor of neurosurgery at Stanford University, where is also the founder and director of the Center for Compassion and Altruism Research and Education. He explores how manifestation is not only a tool to achieve what we want, but it is also fundamentally about being selfless and caring for others in order to activate our deep internal happiness. Link to the advertised Chicago Booth Review Podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast24-202405/02

Why We Die—And How We Can Live Longer, with Nobel Laureate Venki Ramakrishnan

Why We Die—And How We Can Live Longer, with Nobel Laureate Venki Ramakrishnan

They’re perhaps the oldest questions in the science: Why do we die? And could we find a way to live forever? But for decades, anti-aging research was a “backwater” of the scientific community, consider too fanciful and unrealistic. That is until the last few years. Modern advances in biology have taught us a lot about how we age and why we die—could that knowledge help us turn back the clock?In his new book, “Why We Die: The New Science of Ageing and the Quest for Immortality”, Nobel Prize-winning scientist Venki Ramakrishnan delves into the latest science of aging and investigates the nearly $30 billion dollar longevity industry to separate fact from fiction in our modern quest for immortality.

What Dogs Are Teaching Us About Aging, with Daniel Promislow

What Dogs Are Teaching Us About Aging, with Daniel Promislow

Every dog owner has faced the hard realization that their dog won’t live as long as they do, but we’ve all probably wondered: Why do some dogs live longer than others? It turns out that several factors are at play, according to the largest research study of dogs, known as The Dog Aging Project.Prof. Daniel Promislow of the University of Washington is co-director of the project, which examines how biology, lifestyle and environment can increase both the health and lifespan of more than 50,000 dogs. We spoke with Promislow about whether we can help our dogs live longer—and what their research could actually teach humans about aging.Link to the advertised Chicago Booth Review Podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast24-20240404

Where Has Alzheimer’s Research Gone Wrong? with Karl Herrup

Where Has Alzheimer’s Research Gone Wrong? with Karl Herrup

For more than a century, scientists have been studying Alzheimer’s disease and developing theories about its underlying cause. The leading theory for decades has been that abnormal amyloid plaques in the brains of those who suffer from the disease are the central cause. But, according one renowned Alzheimer’s researcher, this myopic focus is not only flawed, but may be holding back our search for a cure. Neurobiologist Karl Herrup argues that we need to go back to the drawing board, redefine the disease and understand the many factors that could cause it before we can race for a cure. A professor of neurobiology and an investigator in the Alzheimer’s Disease Research Center at the University of Pittsburgh School of Medicine, Herrup is the author of How Not to Study a Disease: The Story of Alzheimer’s.

Why Breeding Millions of Mosquitoes Could Help Save Lives

Why Breeding Millions of Mosquitoes Could Help Save Lives

Mosquito-borne diseases are one of the greatest global health threats, infecting around 700 million people every year with Zika virus, dengue fever, malaria and yellow fever — which can all be deadly if left untreated. Unfortunately, the mosquito population is not slowing down, and factors like climate change and increased global travel are broadening the mosquito's range. The effort to stop the mosquito is not an easy task; insecticides and vaccines can't completely stop the spread of these diseases. But instead of trying to kill mosquitoes, one nonprofit is taking a unique approach.Scientist Scott O'Neill is founder and CEO of the World Mosquito Program, a nonprofit group with the goal of eliminating mosquito-borne diseases. The program is implementing a new method of inoculating the wild population of mosquitoes with a bacteria called Wolbachia, which is resistant to diseases. So far, the program has been rolled out in countries like Brazil, Colombia, Indonesia, Australia and Mexico – and has already seen success in reducing rates of disease.Link to the advertised Chicago Booth Review Podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast24-20240307

Why Shaming Other Countries Often Backfires, with Rochelle Terman

Why Shaming Other Countries Often Backfires, with Rochelle Terman

How do you stop a government from continuing to commit human rights abuses? You could take them to an international court of justice, or file a complaint at the UN. But none of those bodies have any enforcement power. Short of going to war, the only option on the table in most international situations is to name and shame. But is that strategy effective?In her new book, “The Geopolitics of Shaming: When Human Rights Pressure Works and When It Backfires,” University of Chicago political scientist Rochelle Terman argues that there is a real dilemma to international human rights pressure: Shaming is most common in situations where it is least likely to be effective; and, most troublingly, it can often make human rights abuses worse. Link to the advertised Chicago Booth Review Podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast24-20240222

Can Trump Legally Be President?, with William Baude

Can Trump Legally Be President?, with William Baude

The Supreme Court’s decision on whether Colorado can take former President Donald Trump off the ballot in the 2024 election may be one of the most consequential in its history. The case will turn on the court’s interpretation of Amendment 14, Section 3 of the Constitution, which bars any previous elected official from holding office if they participated in an insurrection. When making their case, Colorado followed the logic of a law review article co-authored last year by University of Chicago Prof. William Baude. The article drew a ton of attention, in part because Baude is a conservative legal scholar and member of the Federalist Society.As the Supreme Court begins oral arguments on Feb. 8, Baude joined Big Brains to make his case for why he thinks Section 3 applies to Trump. But this isn’t an episode about what should happen at the Supreme Court, it’s about what could happen. Whether you agree with Baude or not, understanding the legal theory behind his argument is crucial to understanding any decision that may come from the court. And, as we walk through the scholarship on Section 3, it’ll become clear that there are more than just two outcomes: on or off the ballot, but many outcomes…some with ramifications—including a possible constitutional crisis—all the way to Jan. 6, 2025.

What Our Hand Gestures Reveal About Our Thoughts, with Susan Goldin-Meadow

What Our Hand Gestures Reveal About Our Thoughts, with Susan Goldin-Meadow

Language shapes our world. But when we speak, there is actually a secret conversation happening beyond our words. It’s happening not with our mouths—but with our hands.Prof. Susan Goldin-Meadow is a distinguished scholar of psychology at the University of Chicago. Her research into deaf children who were never taught sign language led her to studying why the gestures we do all day may contain more information about our minds than we realize. Now she’s included all her insights in a new book, “Thinking With Your Hands—The Surprising Science Behind How Gestures Shape Our Thoughts.”

Psychedelics Without Hallucinations: A New Mental Health Treatment? with David E. Olson

Psychedelics Without Hallucinations: A New Mental Health Treatment? with David E. Olson

The United States is facing a real mental health crisis. In the last few years, one possible treatment has gotten a lot of press: psychedelic drugs. But what is actually happening in a person’s brain when they take a psychedelic? Could understanding the biology and the chemistry allow us to make better and safer versions of these drugs—and maybe even create psychedelics without the hallucinations?In this episode, we speak with Assoc. Prof. David E. Olson, founding director of the UC Davis Institute of Psychedelics and Neurotherapeutics. Olson and his lab have been researching the therapeutic effects of psychedelic drugs and how they could be used to treat neuropsychiatric diseases, including depression, anxiety disorders and even addiction. His lab’s is researching how to develop non-hallucinogenic psychedelics, also called next-generation neurotherapeutics.

The Science Of Happiness

The Science Of Happiness

The Big Brains team is taking some time off during the holidays but for all those travelers out there heading home, we wanted to make sure you still had your favorite podcast in your feed. So, we’re resharing one of our most popular episodes ever. It’s about the science of happiness.What is the key to living a happy and fulfilling life? The answer is actually quite simple, according to the two scholars behind the longest scientific study of happiness every conducted.Beginning in 1938, the Harvard Study of Adult Development tracked three generations of families to uncover what contributed to their happiness. In their new book, The Good Life: Lessons from the World's Longest Scientific Study of Happiness, Robert Waldinger and Marc Schulz tell the stories behind their participants' lives and provide key insights on the recipe to happiness. Marc Schulz, a professor at Bryn Mawr College, joins the podcast to discuss the book and their study.

Do We Really Have Free Will? With Robert Sapolsky

Do We Really Have Free Will? With Robert Sapolsky

Here’s the question you’re going to be asking for the next 30 minutes: Did I freely choose to listen to this podcast, or did I actually have no choice at all? Most of us probably believe we have free will. We feel like we make decisions, and that each of us is responsible for the consequences of our actions. But what if that’s all just an illusion?Robert Sapolsky is a renowned professor of biology and neurology at Stanford University, but he’s also the author of best-selling scientific books such as “Behave”. He’s always been focused on the biological mechanisms that shape our actions, but in his latest book, “Determined: A Science of Life Without Free Will” he’s going a step further: He says the science shows that our biology doesn’t just shape our actions, but completely controls them. In this episode, he argues that letting go of the illusion of free will could radically reshape our world.

A Radical Solution To Address Climate Change, with David Keith

A Radical Solution To Address Climate Change, with David Keith

Climate change can feel like an impossible crisis these days. Every week there is some new report about the irreversible damage we’re doing to our planet and the havoc it will bring to people’s lives. We all know cutting emissions is the solution, yet governments and companies seem no closer to meeting the goals that scientists say we must hit. It can feel hopeless.There is one possible controversial solution to climate change many in the mainstream haven’t discussed. It’s so controversial, in fact, that some experts say we shouldn’t even be discussing it. But University of Chicago Professor David Keith says we need to talk about it. It’s called solar geoengineering—the process in which you reflect a small fraction of sunlight back into space. As the founding director of the Climate Systems Engineering Initiative at UChicago, Keith is leading a team that will research solar geoengineering and other novel solutions to climate change.

How PFAS “Forever Chemicals” Are Harming Our Health, with Linda Birnbaum

How PFAS “Forever Chemicals” Are Harming Our Health, with Linda Birnbaum

By now, you've probably heard about the dangers of PFAS “forever chemicals.” These chemicals are all around us—they're in waterproof hiking boots, electronics, nonstick pans and even our drinking water—but there's no way for them to break down in our environment. Epidemiological studies have linked to these chemicals to numerous diseases—from kidney cancer, liver cancer, obesity, decreased fertility and more.American toxicologist Linda Birnbaum has been sounding the alarms about how PFAS are harming our health for the last few decades. She was previously the director of the National Institute for Environmental Health Sciences at the NIH and is currently an adjunct professor at the University of North Carolina, Chapel Hill. She explains that while we cannot completely avoid PFAS, there are steps we can take to limit our exposure.Subscribe to Big Brains on Apple Podcasts and Spotify.

Are We Worse People Than We Used To Be? With Adam Mastroianni

Are We Worse People Than We Used To Be? With Adam Mastroianni

How many times have you heard this phrase: “Back in the day, people were nicer” or “People aren’t as kind as they used to be?” Most of us have experienced the feeling that people are becoming meaner over time, year after year. But is it true? Are people really less kind than they used to be?That’s the question that has bothered psychologist Adam Mastroianni most of his life. He set out to find an answer—a search that recently culminated in a paper published in the journal Nature titled, “The Illusion of Moral Decline.” While the title may be a giveaway for his findings, he asks: If people are becoming less moral, why do we all feel the same way—and what can we do to shake this “illusion?”Link to the advertised Chicago Booth Review Podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast23-20231102#sort=%40articledate%20descending

Freakonomics’ Steven Levitt On The Secret To Making Tough Choices

Freakonomics’ Steven Levitt On The Secret To Making Tough Choices

Of the academic books that have become household names, “Freakonomics” must be at the top of the list. The 2005 book by University of Chicago scholar Steven Levitt and journalist Stephen Dubner created not only a whole new way of thinking about discovering answers to complex problems, but launched a media empire—from book sequel to a movie to a hit podcast.On this special episode, we sat down with Levitt during the inaugural UCPN Podcast Festival, to talk about the legacy of Freakonomics. Almost 20 years later, he told our audience how he views himself as a “data scientist” and not just an economist, what he’s learned about using a coin flip to make hard decisions in life, and why he thinks he may have found the “holy grail” of solving crime. Link to the advertised Chicago Booth Review Podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast23-20231019

Will Political Violence Destroy Our Democracy?, With Robert Pape

Will Political Violence Destroy Our Democracy?, With Robert Pape

Since the Jan. 6, 2021 attack on the U.S. Capitol, University of Chicago Prof. Robert Pape has been closely observing the threats to our democracy. Now, the renowned terrorism expert says that violent ideas coming from a dedicated minority are moving from fringe to mainstream.In 2021, Pape's team along with NORC at the University of Chicago launched the Dangers to Democracy tracker, an ongoing series of surveys to track Americans' thoughts and attitudes about political violence. In one recent survey, about 12 million Americans said they believe violence is justified to restore Trump to power. Still, Pape believes the data may give us some answers about how to move forward, and how to strengthen the center.

Defending Campus Free Speech In A Polarized Age, with Paul Alivisatos and Tom Ginsburg

Defending Campus Free Speech In A Polarized Age, with Paul Alivisatos and Tom Ginsburg

Free speech is probably one of the most polarizing public topics of debate. And those arguments only become more intense when it comes to free expression on college and university campuses. Should professors be allowed to say whatever they want? What about speakers being invited to campus? Who gets to say what is acceptable and unacceptable?The University of Chicago has had a unique and long history of defending free expression, and this year is building upon that commitment by launching The Chicago Forum on Free Inquiry and Expression. That forum is being led by renowned UChicago law professor Tom Ginsburg. He joins our podcast along with President Paul Alivisatos to talk about why universities must have a commitment to free inquiry—and how this new forum plans to promote free and open discourse, while addressing present-day challenges.

Why The Secret To Health Lies In The Mind-body Connection, with Ellen Langer

Why The Secret To Health Lies In The Mind-body Connection, with Ellen Langer

Can you heal faster just by tricking your brain? Could you lose weight with only a change of mindset? Could you think yourself into being younger? If you think the answer to all these questions is no, you haven’t read the research from renowned Harvard University psychologist Ellen Langer.Langer is a bit of a legend. She’s the first woman to ever receive tenure in psychology at Harvard, and her work has earned her the moniker: “The Mother of Mindfulness”. Her 40-year research career into the mind-body connection—and how mindfulness can hack that system—has delivered some unbelievable results that she believes hold the key to revolutionizing our health. She complies all of her work in her latest book “The Mindful Body: Thinking Our Way to Chronic Health.”

Phonics Vs. Whole Word: The Science Of Reading, With Adrian Johns

Phonics Vs. Whole Word: The Science Of Reading, With Adrian Johns

Reading is one of the most significant practices in the modern age of information, but it has a complicated history. Scientists began studying reading over a century ago; they built eye movement devices to study how fast and efficiently we read, and even proposed methods on the best ways to teach kids how to read. But all of this well-intentioned science led to various debates, from America's Reading Wars to today's anti-elite and anti-science movement. In a new book, The Science of Reading: Information, Media, and Mind in Modern America, Prof. Adrian Johns, chair of the Department of History at the University of Chicago, dives into reading's complicated history and what we can learn from it to better shape the future of reading.

How AI Is Transforming Scientific Research, With Rebecca Willett

How AI Is Transforming Scientific Research, With Rebecca Willett

One of the first areas to be affected by AI has been science. Researchers have already started to integrate these new technologies into their work, but what does it mean to let these systems into our labs? Can they be trusted? And, if they so, how radically can they push science forward?Prof. Rebecca Willett is the faculty director of AI at the University of Chicago Data Science Institute. She is at the forefront of thinking through how AI will change science, and in this episode, she examines the opportunities—and the dangers—of this rapidly emerging technology.