The host of the podcast The Dr. Gabrielle Lyon Show wants to help her listeners achieve longevity. As an experienced functional medicine physician, Dr. Gabrielle Lyon has a good idea of how to do that. It's a method that she created called Muscle-Centric Medicine. Dr. Lyon believes there is too much focus on fat and obesity in the health field. She believes that the real problem is people's lack of muscle mass. In her geriatric and palliative care work, the host saw the importance of muscle. She saw how fragility leads to falls and other illnesses. In her podcast, she focuses on ways to help listeners build their muscles for better health.

Strengthening muscles requires more than lifting weights and working out. According to the podcast host, it's a matter of eating the right food, getting better sleep, taking care of one's mental health, and more. It also requires people to be consistent with their healthy habits. Dr. Lyon examines every aspect of life that can help people become healthier. This includes their environmental and psychological obstacles to lasting health.

The host speaks to a different expert in each episode of The Dr. Gabrielle Lyon Show. Together, they create a complete plan to live better, healthier lives. In one episode, she speaks to Nick Barringer, a dietician for tactical athletes. In another, she talks to former Secret Service Special Agent Evy Poumpouras. They discuss how to read people and handle difficult situations. Other episodes explore the gut microbiome, high-intensity training, and keeping the brain healthy.

One of the strengths of The Dr. Gabrielle Lyon Show is the focus on scientific evidence. In her work, Dr. Lyon conducts clinical trials and research to ensure her methods are valid. She also ensures she only invites guests who can support their claims with evidence. However, this show is not a substitute for real-life medical advice.