The Skeptics' Guide to the Universe is a weekly science news podcast. There are five cohosts. Dr. Steven Novella is a neurologist at Yale School of Medicine. He is also the cofounder of the New England Skeptical Society. Jay Novella sits on the board of the Northeast Conference on Science and Skepticism. He also hosts Alpha Quadrant 6, a podcast that reviews works of science fiction. Cara Santa Maria is a science journalist who has appeared on many major news outlets. Bob Novella is also a cofounder of the New England Skeptical Society. Evan Bernstein gives educational seminars that focus on debunking pseudoscience and paranormal theories.

The theme of The Skeptics' Guide to the Universe is in the title. Every week, the podcast hosts get together to report on that week's news in science. For every story, they provide background information and details. Like the traditional news, the podcast's topics are different every week. The Skeptics discuss the release of a new Alzheimer's drug. They debunk Robert Kennedy's theories. They explain why Canadian forests are on fire. They report progress on technology for flying cars.

Like any good skeptics, the hosts pay special attention to pseudoscience and conspiracies. The podcast questions reports of aliens in Las Vegas. They explain why Jeffrey Epstein was not murdered. They debunk the moon landing hoax theory. Listeners will appreciate the segment in which the hosts respond to emails. As a podcast held to the standards of academia, The Skeptics' Guide to the Universe invites debate. The skeptics read mail from listeners who question their reasoning and explain themselves.

The last segment of each episode is "Science or Fiction?" In it, Steven reads out three statements and invites his cohosts to guess the fabricated one. The statements relate to hard science. In one episode, Steven asks his fellow skeptics about proteins. In another, the theme is medieval jesters. In yet another, it's recent discoveries.

Science enthusiasts might appreciate the commitment to facts in The Skeptics' Guide to the Universe. Listening is a great way to stay informed about the most recent scientific developments.