Get ready for friendly giant viruses, the ancient origins of bioluminescence, sneaky bacteria, R codename Puppy Cup, a Super Mario Bros. explanation of R piping, and grants for rare cancer research. Science On. References: A giant virus infecting the amoeboflagellate NaegleriaEvolution of bioluminescence in Anthozoa with emphasis on OctocoralliaBurkholderia thailandensis uses a type VI secretion system to lyse protrusions without triggering host cell responses[Rd] R 4.4.0 is releasedNavigating the Data Pipes: An R Programming Journey with Mario Bros.NIH: Pathway to Independence AwardNIH: Small Business Transition Grant For Early Career ScientistsDoD: Rare Cancers, Concept AwardGenScript Life Science Research Grant Program R Packages: slap: Simplified Error HandlingRobRegression: Robust Multivariate Regressiondonutsk: Construct Advanced Donut Charts

Get ready for umbrella antibiotics, staring into the nanovoid, blue-whale-sized ichthyosaurs (maybe), and astrodynamics knot theory applications. Science On! References: Streptomyces umbrella toxin particles block hyphal growth of competing speciesBeyond nothingness in the formation and functional relevance of voids in polymer filmsThe last giants: New evidence for giant Late Triassic (Rhaetian) ichthyosaurs from the UKApplications of knot theory to the detection of heteroclinic connections between quasi-periodic orbitsDistributions with specified skewness and kurtosisHow to Make Mobile Apps with R Shiny R Packages: filters: A "Snake_case" Filter System for Rrelcircle: Draw Regulatory Relationships Between Genes

Get ready for the pan-cancer microbiome, auto-parameterizing 3D printing, Bergmann’s rule busted for dinosaurs, and Proca stars made out of dark matter. Science On! References: A pan-cancer analysis of the microbiome in metastatic cancerHuman brain small extracellular vesicles contain selectively packaged, full-length mRNAOnline Measurement for Parameter Discovery in Fused Filament FabricationAn integrated metagenomic, metabolomic and transcriptomic survey of Populus across genotypes and environmentsGlobal latitudinal gradients and the evolution of body size in dinosaurs and mammalsProca stars with dark photons from spontaneous symmetry breaking of the scalar field dark matterJournal of Statistical Software Volume 108The Truth About Tidy Wrappers R Packages: IRR2FPR: Computing False Positive Rate from Inter-Rater ReliabilityWayFindR: Computing Graph Structures on WikiPathwaysCARMS: Continuous Time Markov Rate Modeling for Reliability Analysis

Get ready for neoavian phylogenetics, marvelous metafluids, the search for dark photon dark matter, normalization and scaling in R, Highcharts for interactive and animated charts, and a grant on rare diseases. Science On. References: A region of suppressed recombination misleads neoavian phylogenomicsShell buckling for programmable metafluidsFirst Results from a Broadband Search for Dark Photon Dark Matter in the 44 to 52 μ eV Range with a Coaxial Dish AntennaAdd a second axis to a SAS graph6 New books added to Big Book of RA Practical Guide to Data Normalization in RScaling Your Data to 0-1 in R: Understanding the RangeR Highcharts: How to Make Animated and Interactive Data Visualizations in RNCATS: Preclinical Proof of Concept Studies for Rare Diseases R Packages: CoreMicrobiomeR: Identification of Core Microbiomescimo: Extra Recipes Steps for Dealing with Omics Data

Get ready for the smallest starquake, migraine risks in young stroke, tardigrade biostasis, too many colors spoiling the graph, Bioconductor Conference 2024, and a subset of Department of Defense grants on human health. Science On. References: Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s diseaseExpanding the frontiers of cool-dwarf asteroseismology with ESPRESSOAssociation of Traditional and Nontraditional Risk Factors in the Development of Strokes Among Young Adults by Sex and Age Group: A Retrospective Case-Control StudyLabile assembly of a tardigrade protein induces biostasisCRTFASTGEEPWR: A SAS Macro for Power of Generalized Estimating Equations Analysis of Multi-Period Cluster Randomized Trials with Application to Stepped Wedge Designstoo many colors spoil the graphBioconductor Conference 2024DoD Peer Reviewed Medical, Investigator-Initiated Research AwardDoD Peer Reviewed Medical, Discovery AwardAAAAI Foundation Award to Sustain Research Excellence R Packages: CvmortalityMult: Cross-Validation for Multi-Population Mortality ModelsflexOR: Flexible Odds Ratio CurvesglmMisrep: Generalized Linear Models Adjusting for MisrepresentationbiopixR: Extracting Insights from Biological Images

Get ready for leafhopper cloaking technology, the question of a dark matter-less universe, life at the extremes of inactive hydrothermal vents, not caring about the Levene’s test, and a grant on brain changes across longer time spans. Science On. References: Geometric design of antireflective leafhopper brochosomesTesting CCC+TL Cosmology with Observed Baryon Acoustic Oscillation FeaturesInactive hydrothermal vent microbial communities are important contributors to deep ocean primary productivityExploring Andean High-Altitude Lake Extremophiles through Advanced ProteotypingTwo-dimensional materials by large-scale computations and chemical exfoliation of layered solidsassumptions of linear models are about errors, not the response variableHere is why I don’t care about the Levene’s testNIH: New Approaches for Measuring Brain Changes Across Longer Timespans (R01)NIH: New Approaches for Measuring Brain Changes Across Longer Timespans (R21) R Packages: xega: Extended Evolutionary and Genetic Algorithmstidyrates: Tidy Epidemiological Ratescalmr: Canonical Associative Learning Models and their Representationsggbrick: Waffle Style Chart with a Brick Layout in 'ggplot2'

Get ready for bile acid modification, Pizza Pi, pre-print propensity using R, and a grant on misfolding proteins. Science On. References: High-quality semiconductor fibres via mechanical designTrabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genesThe underappreciated diversity of bile acid modificationsNewsletter March 2024 - Genie Builder Beta Launch - Create Web Apps and Dashboards EasilyPizza piMy Simple Understanding of Total Effect = Direct Effect + Indirect Effect (via Mediator)Mastering Random Sampling in R with the sample() FunctionPre Self: what fraction of a journal’s papers are preprinted?NIH: Exploring Proteogenomic Approaches to Unravel the Mechanisms of Mis-Folded Protein Accumulation in Tauopathies R Packages: glmpermu: Permutation-Based Inference for Generalized Linear Modelscorrmeta: Correlated Meta-Analysis

Get ready for low-oxygen Europa, low-mutational nematode genomes, museum-loads of 3D scanned vertebrates, A Steve’s Data Tips and Tricks hat trick plus one, and a NSF grant on AI and math. Science On. References: Oxygen production from dissociation of Europa’s water-ice surfaceEnvironmental radiation exposure at Chornobyl has not systematically affected the genomes or chemical mutagen tolerance phenotypes of local wormsDecoding chromatin states by proteomic profiling of nucleosome readersScientists CT scanned thousands of natural history specimens, which you can access for freeA Beginner’s Guide to Renaming Data Frame Columns in RHow to Rename Factor Levels in R (With Examples)How to Add New Level to Factor in RFiltering Rows in R Where Column Value is Between Two ValuesNSF: Artificial Intelligence, Formal Methods, and Mathematical Reasoning R Packages: DiscreteDatasets: Example Data Sets for Use with Discrete Statistical Testsrexer: Random Exercises and Exams Generator

Get ready for the brightest quasar of them all, biomolecule chirality mysteries, a Biomedical Engineering roadmap, the release of R’s Angel Food Cake, the release of JuliaHub’s Genie Builder, and Shiny for clinical trial reporting. Science On. References: The accretion of a solar mass per day by a 17-billion solar mass black holeSymmetry breaking and chiral amplification in prebiotic ligation reactionsGrand Challenges at the Interface of Engineering and MedicineR 4.3.3 is releasedUnveiling Genie Builder: Create Low-Code Apps on JuliaHubOn using flexible distributions to fit dataUsing colors to visualize groups in a bar chart in SASWhat Good is Analysis of Variance?Escape the Spreadsheet Inferno: Switch to Shiny for Clinical Trial ReportingDemystifying the melt() Function in R R Packages: pctax: Professional Comprehensive Omics Data AnalysisclusEvol: A Procedure for Cluster Evolution Analyticsvolker: High-Level Functions for Tabulating, Charting and Reporting Survey Data

Get ready for blazing computer processing speeds, a link between fine particulate matter and Alzheimer’s Disease, mammalian gene insertion with bird retrotransposons, experimental confirmation of altermagnets, The Journal of Statistical Software Volume 108, a free R/Shiny eBook, and an NSF grant on acceleration of protein design. Science On. References: Simultaneous and Heterogenous MultithreadingAssociation of PM2.5 Exposure and Alzheimer Disease Pathology in Brain Bank Donors—Effect Modification by APOE GenotypeHarnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor lociObservation of New Isotopes in the Fragmentation of 198 Pt at FRIBObservation of time-reversal symmetry breaking in the band structure of altermagnetic RuO2Journal of Statistical Software Volume 108On using the range to estimate the variability of small samplesmeasures of model fit for linear regression modelsLevel Up Your R/Shiny Team Skills with Our Free EbookEnhancing Your Plots in R: Adding Superscripts & SubscriptsNSF: Ideas Lab: Use-Inspired Acceleration of Protein DesignNSF: Plant Genome Research Program R Packages: fluidsynth: Read and Play Digital Music (MIDI)aberrance: Detect Aberrant Behavior in Test Dataggbrace: Curly Braces for 'ggplot2'

Get ready for a mini Mimas ocean, microbes for low-cost molecular biology, Ordovician fossils from France, a 3D-printed titanium metamaterial, Emacs for R, and a NASA omnibus funding announcement chock full of opportunity. Science On. References: A recently formed ocean inside Saturn’s moon MimasEfficient natural plasmid transformation of Vibrio natriegens enables zero-capital molecular biologyThe quest for superheavy elements and the limit of the periodic tableThe Cabrières Biota (France) provides insights into Ordovician polar ecosystemsPleural macrophages translocate to the lung during infection to promote improved influenza outcomesTitanium Multi-Topology Metamaterials with Exceptional StrengthAn exact formula for the sampling distribution of the correlation coefficientNIA Career Transition AwardNASA ROSES: Astrophysics Data Analysis ProgramNASA ROSES: New Frontiers Data Analysis ProgramNASA ROSES: Exobiology R Packages: circlesplot: Visualize Proportions with Circles in a Plotmulte: Multiple Treatment Effects Regressionvalentine: Spread the Love for R Packages with Poetry

Get ready for memory B cells that react to allergens, a cosmic chicken and egg questions with black holes and galaxies, the ecological importance of tiny plankton, the spectacular shape of ancient trees, triangular art in Julia, elliptical hearts in SAS, and the 400th entry in the Big Book of R. Science On. References: Type 2–polarized memory B cells hold allergen-specific IgE memoryLocomotion and the early Mesozoic success of ArchosauromorphaWhich Came First: Supermassive Black Holes or Galaxies? Insights from JWSTActivation of CBASS Cap5 endonuclease immune effector by cyclic nucleotidesThe silent majority: Pico- and nanoplankton as ecosystem health indicators for marine policyNoninvasive neuromodulation of subregions of the human insula differentially affect pain processing and heart-rate variability: a within-subjects pseudo-randomized trialmicrobeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics dataLung endothelium exploits susceptible tumor cell states to instruct metastatic latencyEnigmatic fossil plants with three-dimensional, arborescent-growth architecture from the earliest Carboniferous of New Brunswick, CanadaMichael Dickey, our guide through the surprising world of liquid metalsMy First Julia Package – TriangulArt.jlNewsletter February 2024 - Next Gen Battery Simulation with JuliaSimThe elliptical heart9 for SAS9 – Top Tips for SAS 9 Programmers Moving to SAS ViyaHow to Check if Date is Between Two Dates in RBig Book of R at 400 [New milestone!] R Packages: fastTS: Fast Time Series Modeling with the Sparsity Ranked Lassoflowchart: Tidy Flowchart GeneratormulSEM: Some Multivariate Analyses using Structural Equation Modeling

Get ready for a newborn great white shark sighting, an ancient Martian lakebed, a potential new kingdom of viruses, the twin mysteries of correlation and covariance in R, and a clinical trial grant focused on natural products. Science On. References: Novel aerial observations of a possible newborn white shark (Carcharodon carcharias) in Southern CaliforniaGround penetrating radar observations of the contact between the western delta and the crater floor of Jezero crater, MarsDouble-stranded RNA sequencing reveals distinct riboviruses associated with thermoacidophilic bacteria from hot springs in JapanThe name of the variable that contains the largest value in each rowHow to split a large file into smaller chunks using SASShadow and Substance: Unveiling the Twin Mysteries of Correlation and CovarianceNCCIH: Natural Product Early Phase Clinical Trial Phased Innovation Award R Packages: NoviceDeveloperResources2: Further Resources to Assist Novice Developersfastglmpca: Fast Algorithms for Generalized Principal Component Analysismodelfactory: Combine Statistical Models into a Tibble for Comparisonunigd: Universal Graphics Device

Get ready for blockchain for biology, ancient microbe metabolisms, false vacuum decay evidence, angles vs. slopes, and a grant on convergence research. Science On. References: Three-dimensional nanoscale metal, metal oxide, and semiconductor frameworks through DNA-programmable assembly and templatingEmergence of metabolic-like cycles in blockchain-orchestrated reaction networksAspects of the biological carbon cycle in a ca. 3.42-billion-year-old marine ecosystemPhylogenomic insights into the first multicellular streptophyteFalse vacuum decay via bubble formation in ferromagnetic superfluidsAngles vs slopes: The statistics of steepnessThe Art of Estimation in R: Confidence Intervals Demystified6 Benefits of R {targets} for Data Science WorkflowsNSF: Growing Convergence Research R Packages: labeleR: Automate the Production of Custom Labels, Badges, Certificates, and Other Documentslabelr: Label Data Frames, Variables, and Valuesgbm3: Generalized Boosted Regression ModelsNVAR: Nonlinear Vector Autoregression Models

Get ready for an ancient black hole, capturing the complexity of fragile ocean life, the magnetic map of the Milky Way, Six not-so-basic R functions, the Six degrees of Hadley Wickham, and a grant on agricultural genomes to phenomes. Science On. References: A small and vigorous black hole in the early UniverseContrast Agent-Free 3D Renal Ultrafast Doppler Imaging Reveals Vascular Dysfunction in Acute and Diabetic Kidney DiseasesAn in situ digital synthesis strategy for the discovery and description of ocean lifeImproved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integrationDisentangling microbial networks across pelagic zones in the tropical and subtropical global oceanTomographic Imaging of the Sagittarius Spiral Arm's Magnetic Field Structurecharting a path to statistical confidence and masterySix not-so-basic base R functionsSix degrees of Hadley Wickham: The CRAN co-authorship networkCreating automatically dozens of calendar notifications (with R)USDA: Agricultural Genome to Phenome Initiative R Packages: neonPlantEcology: Process NEON Plant Data for Ecological AnalysisNGCHM: Next Generation Clustered Heat Mapsscientific: Elegant Scientific Themed Reporting for 'Markdown'MetaNet: Network Analysis for Omics Datatreestats: Phylogenetic Tree Statisticsr2fireworks: Enhance Your 'Rmarkdown' and 'shiny' Apps with Dazzling Fireworks Celebrations

Get ready for rolling ringbots, cancer cannibalizing cells, the R Journal Volume 15/3, a new Bioconductor website, a beginner's guide to probability distributions in R, and an EPA grant to reduce air pollution in schools. Science On. References: New Soft Robots Roll Like Tires, Spin Like Tops and Orbit Like MoonsHyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killingMicrobiome homeostasis on rice leaves is regulated by a precursor molecule of lignin biosynthesisBdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hostsR Journal Volume 15/3Blog posts from 2023 that deserve a second lookBioconductorRetrieving Data From The Bottom Of The OceanUnveiling the Smooth Operator: Rolling Averages in RProbably More Than Chance: A Beginner’s Guide to Probability Distributions in RGoodbye Complicated Dropdowns: Welcome to the New Era of Human Readable FiltersFinancial Assistance is Available for Your R User Group in 2024!EPA: Grant Funding to Address Indoor Air Pollution at SchoolsNSF: Research in Basic Plasma Science and Engineering R Packages: Apoderoides: Prioritize and Delete Erroneous Taxa in a Large Phylogenetic Treebscui: Build SVG Custom User InterfacedittoViz: User Friendly Data VisualizationtidyMC: Monte Carlo Simulations Made Easy and Tidytidyplate: Transform Microplate Data into Tidy Dataframes

Get ready for lava-proof ceramics, antibiotic polymers, Trojan horse plant mRNA vesicles, microbiome disturbances in kidney stone formation, Top 10 DO Loop posts from 2023, Mastering Lowess Smoothing in R, and early career grants with no existing preliminary data. Science On. References: Disordered enthalpy–entropy descriptor for high-entropy ceramics discoveryA giant stem-group chaetognathRing-opening metathesis polymerization of N-methylpyridinium-fused norbornenes to access antibacterial main-chain cationic polymersThe bacterial replication origin BUS promotes nucleobase capturePlant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infectionMulti-site microbiota alteration is a hallmark of kidney stone formationTop 10 posts from The DO Loop in 2023Mastering Lowess Smoothing in R: A Step-by-Step GuideFour ways to streamline your R workflowsThe 6 steps to finally lose weight (or solve almost any other problem) (with R code)NIH: Stephen I. Katz Early Stage Investigator Research Project Grant (clinical trial)NIH: Stephen I. Katz Early Stage Investigator Research Project Grant (non-clinical trial) R Packages: allofus: Interface for 'All of Us' Researcher WorkbenchARGOS: Automatic Regression for Governing Equations (ARGOS)MSML: Model Selection Based on Machine Learning (ML)surveyexplorer: Quickly Explore Complex Survey Data

Get ready for a brief, asynchronous episode today to cover the break over the Christmas holiday. Merry Christmas! References: Science News Most Popular Stories 2023Smithsonian Magazine Most Significant Science Stories 2023IEEE Top Programming Languages 2023Top R packagesExercismGrants.gov

Get ready for unnatural nucleotides, nutrient-blocking gut microbes, a confluence of newsletters and conferences, Effortless Cool in Data Science, and a grant for long-term ecological research. Science On. References: A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymeraseMicrobiome diversity protects against pathogens by nutrient blockingRegistration for useR! 2024Python Software Foundation - December 2023 NewsletterJulia Newsletter December 2023New SAS Training Course: Statistics You Need to Know for Machine Learningwhen the hessian matrix goes wackyA three-arm trial using two-step randomizationA new focus on tidygraphEffortless Cool Is A Detailed Process – How To Influence, Tell Better Stories, and Become More PersuasiveGitHub: Javascript Interview QuestionsNHGRI: Advancing Genomic Technology Development for Research and Clinical ApplicationNSF: Long-Term Ecological Research R Packages: AVGAS: A Variable Selection using Genetic AlgorithmstreesliceR: To Slice Phylogenetic Trees and Infer Evolutionary Patterns Over Timesfd: Space-Filling Design Libraryexplainer: Machine Learning Model Explainer

Get ready for Japanese mosasaurs, hard-as-diamond materials, cold ocean exoplanets, polychoric correlation, 15 Academic Research Tools, the 10 most popular R books of 2023, and an NSF grant for Emerging Mathematics in Biology. Science On. References: A new derived mosasaurine (Squamata: Mosasaurinae) from south-western Japan reveals unexpected postcranial diversity among hydropedal mosasaursSynthesis of Ultra-Incompressible and Recoverable Carbon Nitrides Featuring CN4 TetrahedraProspects for Cryovolcanic Activity on Cold Ocean PlanetsDiscovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand ChemotypeWhat is polychoric correlation?what is family-wise error rate?Top 15 Academic Research Tools For Scholars And TutorsThe 10 most popular R books of 2023Edge of Tomorrow: Preparing R Functions for the UnexpectedNSF: Emerging Mathematics in Biology R Packages: DFBA: Distribution-Free Bayesian Analysisdunlin: Preprocessing Tools for Clinical Trial Datashinyquiz: Create Interactive Quizzes in 'shiny'TaxaNorm: Feature-Wise Normalization for Microbiome Sequencing Datasimtrial: Clinical Trial Simulation