25% or Higher Savings on Supplements for WiseAthletes Everybody knows exercise is good for us but why? And why doesn't my food tracker balance my calories even when I weigh my food and use a power meter and heart rate monitor to track energy usage? Do I really have to step on a scale everyday to know if I am eating too much? And how can I tell if I'm eating too little to build muscle and to avoid bone and immune function issues down the road? Today on episode 132 I am joined by Hari Mix, a Stanford University PhD and the Founder and CEO of Calorify, an emerging technology company providing athletes and sports teams with the world's most accurate measurement of energy expenditure, powered by doubly labeled water. Only by accurately measuring metabolic activity can athletes and everyday people know if we are consuming too much or too little food to power our athletic pursuits and the bodily functions that repair our bodies and keep us healthy for a long time. Hari Mix explains that professional athletes are shifting from "how little can I eat and still perform" to "how much can I eat to perform better", and he walks us though what is known about these complicated and vexing questions about balancing calories in vs. out, and why exercise is not a great tool for losing weight. The image below is a weak illustration of the idea that your metabolism changes in response to changes in energy availability / left over after exercise. It works both ways: too little available energy will turn down metabolic rate while too much energy availability will turn up the metabolic rate. The metabolic rate of energy usage is indicative of bodily function activity level: energy surplus: growing muscles and bones and other organs, energy shortage: scavenging of old and damaged proteins in muscles, bones, immune cells, etc. (autophagy, mitophogy): Related info and episodes: Episode 131 - Supplement Quality & EfficacyEpisode 129 - Bone HealthExample Calorify reportMetabolism by Age chart (full image) More Hari Mix & Calorify info: Exercise Paradox article by Dr Pontzercalorify.com Want to support the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes.

Fullscript for WiseAthletes I think it is clear that nutritional supplements are a useful and medically legitimate way for me to meet my nutritional needs and support my efforts to be a strong athlete for a long time. Yet, the question of which nutritional supplements to buy turns out to be much more complicated than it appears … my conversation today will make that challenge less overwhelming.  If you have ever dared to wonder if that nutritional supplement you have been taking for the last year with no or little effect really contains the real botanical or amino acid or whatever you wanted and expected, then you have already realized you have no idea and no way to find out.  Sure, you can use 3rd party services like ConsumerLab but that can’t tell you if the bottle in your hand is the same as the one they tested.  So what is a wise athlete to do? Today on episode 131 I am interviewing Dr Jeff Gladd who is a medical doctor with his own clinic and the chief medical officer of Fullscript, a wholesale nutritional supplement fulfillment service serving over 6 million patients through 100,000 healthcare providers. Dr Gladd knows the ins and outs of the nutritional supplement business, and he shares his tips for how to find brands and to source product that provides the best chance of having the purity and potency you and I seek.   And he also shared his advice on specific supplements for the older athlete.  And be sure to explore the WiseAthletes Fullscript site where you can see for yourself if the product selection and pricing is as good as the quality control offered by FullScript. I am no longer buying from Amazon as I have done for years. It's time for me to make sure I am getting the purity and potency I need.  Bullet points: Navigate the nutritional supplement industry by focusing on quality first and then cost. A quality product in your hand can only come through quality control maintained throughout the manufacturing and distribution process...any step along the way with a company you can't trust and that hasn't been checked by 3rd party certifiers means you don't know what you are getting.Start with goals: what are you trying to accomplish: (1) do everything you can through lifestyle improvement, (2) then turn to supplements to fill in gaps: start at the top...what are the most important things to address, (3) don't take 25+ supplements...take 5-6 high quality nutritional aids that you can expect to work, and then test to be certain, (4) move onto the next thing to address.Certifications available: Certified Gluten Free, Vegan, Vegetarian, cGMP, NSF, Kosher Check, Certified Vegan, Certified Halal. UL, Informed-Choice, Informed-Sport, Friend of the Sea, Certified B Corporation, Non GMO Verified, USP, USDA Organic, GOED, IFOS, ISO, Certified Organic, Certified B Corporation®, NSF Certified for Sport, MOSA Certified Organic, QAI, Homeopathic, Clean Label Project™, MSC Fish, 1% For The Planet, Non-GMO, NSF Certified, Halal, Keto Certified, Plant-Based CertifiedAllergen indicators. Animal product free, Artificial color free, Artificial flavor free, Artificial preservative free, Artificial sweetener free, Casein free, Corn free, Crustacean/shellfish free, Dairy free, Egg free, Fish free, Gluten free, GMO free, Grain free, Grass-fed, Hydrogenated oil free, Hypoallergenic, Keto friendly, Kosher, Mustard free, Organic, Paleo friendly, Peanut free, Preservative free, Rice free, Salicylate free, Salt free, Sesame free, Soy free, Starch free, Sugar free, Tree nut free, Wheat free, Whey free, Yeast free Related info: As Chief Medical Officer, Dr. Jeffrey

25% or Higher Savings on Supplements for WiseAthletes Breathing is the essence of life. Yet lung function declines as we age. The chemicals and small particles breathed into our lungs leave a mark and reduce lung function, a little here and a little there. But we can slow the decline, and we can even recover lost function with targeted effort. Do you know how to protect and strengthen your lungs? Today I am joined by MeiLan K. Han, MD, a pulmonologist and the Chief of Pulmonary and Critical Care at the University of Michigan, and a national spokesperson for the American Lung Association. Dr Han is also the author of Breathing Lessons ... a rallying cry for lung health. With the authority that only a practitioner and medical researcher can deliver, Dr Han reveals the latest scientific thinking about the leading respiratory risks — including indoor and outdoor pollution, smoking and vaping, and wildfire smoke during outdoor exercise — and offers practical advice on how to protect the lungs. Listen in to learn about treating your lungs well and maintaining or recovering effortless breathing as you age. Related info and episodes: Episode 103 - Nitric Oxide w/Beth ShirleyEpisode 50 -- Breathing is a Skill w/ George Dallam, PhDAir Quality Index info More Dr MeiLan K. Han info: DrMeilanHan.comDr Meilan Han on X (Twitter)Breath Lessons book on AmazonDr Melan Han website@meilanhan on both Instagram and Facebook Want to support the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNTS

25% or Higher Savings on Supplements for WiseAthletes This is part 2 of my bone health exploration, and this time the question is what should I do if I have osteoperosis? Is it game over? No. Absolutely not. But you will need to work hard to recover the bone health you lost. Doug Lucas, DO, Board Certified Orthopedic Surgeon and Anti-Aging Specialist, will give you insight into the lifestyle, nutrition, testing, and medical solutions for Osteoporosis management and yes, possibly, even reversal. Avoiding pharmaceuticals if at all possible. Dr Doug Lucas is a double board certified physician specializing in optimizing healthspan and bone health. Seven years after completing his training at Stanford and starting his career as an orthopedic surgeon Dr Doug left the traditional medical model to pursue a second fellowship and board certification in anti-aging and regenerative medicine and achieve the status of fellow in Anti-Aging and Metabolic Medicine. Dr Doug has gone on to build a team of experts to help optimize patient's health and help them to live better, longer. The vision has come to fruition with 100s of patients seeing success by reversing chronic diseases like osteoporosis and diabetes but also by improving energy, performance and vitality. Bullet points Layers for building health…start at the foundation and build up….Lifestyle (sleep, diet, stress mgmt., activity, sunshine, social, spiritual)…lots of these things can be done together…time efficiency is important.Keys to get right:  enough protein, enough calcium, the right dairy (A1 vs A2 casein) if possible?  Fermented …full fat is better?  a calm immune system, the right exercise/activity, sleep, stress mgmt stuff to avoid:  alcohol, salt, caffeine, fasting, yo-yo dieting, HPF highly processed food…antibiotics?  Proton pump inhibitors?  NSAIDs (aspirin?) Supplements based on need, which means testing (how do you test?  Anything beyond the standard panels?  How do you assess status or need?  I’m used to my doctors who say anything in the “normal range” is good enough…what other biomarkers do you use….BP, RHR, …any functional markers like grip strength or balance?Other related to testingWhat about allergies?  I’ve heard food allergies are an issue but is it the same for airway allergies like pollen or dust creating histamines?  Do antihistamines help?Melatonin?  Help with sleep and bones?What about non-chemical interventions?  Red/NIR light, UVB lamps, vibration plates, etc.Hormone optimization  — lifestyle then replacement based on real need.  But hormones affect more than bone….right?  Estrogen is the key for bone health?  How do men get enough estrogen for bones?Peptides – gray area….is this an area people should be careful about?  Stuff you can get online…can you trust it?Pharma – medications tend to be very powerful and have side effects.  Anything common that you find contributed to the bone health issues?  How do you deal with polypharmacy issues….accumulation of drugs taken forever?Longevity interventions?  Off-label?  Optimization of biomarkers vs. “normal range”?   (rapamycin?  MB?  ….a long list of off-label medications found to extend healthspan and lifespan in mice:  acarbose, metformin (when combined with rapa), SGLT2 inhibitors (canagliflozin)…and others. Related info and episodes:

25% or Higher Savings on Supplements for WiseAthletes Mitochondria are the powerhouse of the cell, as we learned in high school biology. What's emerging from science more recently is how unhealthy mitochondria are at the heart of many diseases, and even shows up in our daily lives as feeling chronically fatigued or having brain fog. Improving mitochondrial function is at the heart of everything we do for athletic performance, health, and athletic longevity. Heck, mitochondrial dysfunction is one of the 12 hallmarks of aging...so what can we do? Today I am speaking with Dr. Scott Sherr who says "he is a conductor of all things optimal health & performance"....he says everything he does for his patients...whatever their issues are...is usually aimed at improving mitochondrial dysfunction. Dr Sherr is not just a medical doctor …his unique background has led him to build a medical practice combining the best of traditional and alternative medicine. Dr. Scott Sherr is a Board Certified Internal Medicine Physician and a specialist in Hyperbaric Oxygen Therapy (HBOT).  His clinical practice includes Health Optimization Medicine as its foundation plus an integrative approach to hyperbaric oxygen therapy, trargeted supplementation, synergistic new & ancient technologies, and more.  He is the perfect doctor to speak to the Wise Athletes podcast. But there is still more.  Dr. Scott is also the COO of Smarter Not Harder, the company behind Troscriptions, a line of unique supplements to optimize brain and body energy production and to relax and calm when needed.  And, as you will soon hear, Dr Sherr is the person who convinced me to try Methylene Blue, which has served to banish afternoon brain fog from my life. Bullet points (from Smarter Not Harder's THE ULTIMATE GUIDE TO METHYLENE BLUE) THE MAGIC HAPPENS AT LOW DOSES At low doses (MB also works as an acceptor of free electrons from reactive oxygen and nitrogen species (i.e. it works like an antioxidant...one as powerful as vitamin C or glutathione, in fact). There are very few compounds that cycle electrons (i.e. donates and accepts them) as effectively as MB.MB also increases the cytochrome oxidase (complex IV) function in your mitochondria and drives increased glucose consumption. The latter occurs because, when the mitochondria are making more energy, they need more substrate to supply electrons to the electron transport chain. While increasing glucose consumption and energy production, MB also increases the supply of NAD+.At MB can bypass potentially dysfunctional mitochondrial complexes I and II. This is why MB works to reverse or compensate for mitochondrial damage.MB concentrates in tissues with the most mitochondria (e.g. the brain where it readily crosses the blood-brain barrier) the heart, muscles, the liver, and kidneys.But...at moderate doses (3mg to 10mg/kg in most studies), MB becomes an electron donor and a pro- oxidant that facilitates the generation of singlet oxygen and peroxide radicals, especially in the presence of certain spectrums of light. This is likely the way MB works in septic shock (via nitric oxide synthase inhibition) and possibly in cancer treatment. Moderate doses c

25% or Higher Savings on Supplements for WiseAthletes The surprising truth is that bone health is one of the key levers of health and longevity for men and women. Bone health is a driver AND a symptom of overall health that declines steadily past the age of 30. Yet, it is slow to give us feedback on our mistakes...it is a lagging indicator that is hard to fix once low bone density and/or quality have arrived. Do. Not. Let. It. Happen. I used to think I didn't need to worry about my bone health because I was a strong and active athlete my whole life. But I was wrong. Osteoporosis afflicts 50% of all women and 20% of all men, including life-long athletes who "did everything right". Today, on episode 127, I am joined by Dr. R. Keith McCormick to talk about Great Bones. Dr McCormick was an Olympic athlete who discovered 1st hand how "doing everything right" does not keep you safe from osteoporosis. His journey from Olympic athlete to bone fractures from osteoporosis at 45 years old, and back to competitive athlete at 69 years old has informed his deep knowledge about losing and regaining bone health. In his book, Great Bones, Dr McCormick explains not just the fundamentals of osteoporosis and the mechanics of bone loss and regaining skeletal health, but also what you and I can do to slow the decline in bone density and quality so we can keep our bone great bones well into our 60s, 70s, and beyond. In our chat today, Dr McCormick share a little of this knowledge with us. This episode is a bit long and we get into the weeds but there is important information shared all the way to the end.  Take your time, and get to the end. You will learn a ton about the hows and whys about having great bones. And how to avoid weak bones and fractures and the fear of fractures that may come for you if you are not careful. I can promise you that I am being careful starting now. Bullet points Bone health is a symptom and a driver of overall healthBone health drugs can buy time if you've fallen too far, but they are not a long term solution. Don't need them..Bone breakdown and bone building is an all the time thing, just like muscle; if either breakdown or buildup gets out of wack you lose the balance and you lose bone density and quality.You have to signal to the body that you need strong bone. But you also need the substrates to build bone AND a clear signaling to the bone stem cells (immune system issues, inflammation issues, fat cells in bone marrow, etc)For Great Bones, you need: 1.2g/kg/day of high quality protein (collagen is good but doesn't count toward protein intake). Can take leucine and alpha ketogluterate to boost anaerobic effect of protein Low chronic inflammation; over-active immune system is bad for bone (watch gluten and dairy). Also, long cardio sessions increase inflammation which is bad for bone.Frequent high impact activity (2x/day for 30 minutes is ideal); resistance exercise is the keyA healthy gut for absorption of nutrients & avoiding immune system over-activation: lots of fiber, digestive enzymes (acidic digestion), herbs: berberine (good for gut and for bone)Sufficient nutrients, including calcium (not carbonate; 150-200mg a few times a day), magnesium (not carbonate); keep sodium in check; watch ironGet enough Vit D (test for 40-60 nanograms/ml; commonly 1000-5000iu/day) and Vit K (1 & 2 MK- 4&7). Omega 3 are helpful. Healthy s

25% or Higher Savings on Supplements for WiseAthletes Healthspan is all the rage now but beyond a healthy lifestyle what does that really mean? How can it be done? And what can I do now to ward off problems before the illness shows up? Today on episode 126, I am joined by Nathan Price, PhD, Chief Scientific Officer of Thorne HealthTech and co-author of the book, The Age of Scientific Wellness (2023). If there is anyone on the planet who can tell us how we can make this shift from merely treating illness to keeping ourselves healthy for a long, active life......Dr Price is just that person. Dr Price has been at the forefront of creating Precision Medicine as a co-founder of Arivale and Associate Director of the Institute of Systems Biology, and now he is helping Thorne to bring Precision Medicine to you and me. In case you don't remember, Arivale was that way ahead of its time company that offered ongoing wellness and nutritional coaching tailored to the results of each person’s genetic, blood and microbiome tests. Actual personalized medicine. Today, most doctors wait for clinical symptoms to appear before they act, and the ten most commonly prescribed medications confer little benefit to most people taking them. Nathan Price (and his co-author Leroy Hood) argue that we must move beyond this reactive, hit-or-miss approach to usher in real precision health―a form of highly personalized care they call “scientific wellness.” Using information from our blood and genes and tapping into the data revolution made possible by AI, doctors can catch the onset of disease years before symptoms arise, revolutionizing prevention. They say this approach is just getting started but has already had amazing results: diabetes reversed, cancers eliminated, Alzheimer’s avoided, autoimmune conditions kept at bay. All right, let's talk to Nathan Price about the technologies emerging this year and his thoughts on what wise athletes can do right now to slow the rate of aging. Bullet points Scientific Wellness -- a remaking of healthcare from reactive, reductionist reducing of symptoms ... to... figuring out how to keep people healthy while they are healthy...extend the span of time in health..."healthspan"Thorne Ventures...dedicated to launching a platform for health venturesLearned a ton from thousands of measurements over many yearsThe most commonly prescribed drugs have a wide variety of effectiveness on individuals for many reason: microbiome, genome, etc.In 13% of prescribed drugs (including statins), the drug is transformed in the gut by bacteria before being absorbed. So the effect on each person is dependent upon the bacteria in the gutOnce a person hits 50, a healthy person's gut microbiome begins to be less and less like anyone else's gut microbiome.There is no average personExamples:LDL cholesterol lowering: Genome identification of individuals with predisposition for high LDL....no way to lower LDL by lifestyle alone...need medication Weight loss: People with gut microbiome's (identified with fecal matter testing) that produced more SCFA lose weight more successfully Individual testing to find personalized health solutions: Genetic testingNormal blood markers for healthMetobolomics --- 1000 small molecules....chemical markers in bloodSeveral 100 Proteins -- Proteomics in blood (for discovery purposes) "Digital Twin" simulations -- a computer model of a human being that can comprehend status and changes in biomarkers to predict health issues and identify health interventions

25% or Higher Savings on Supplements for WiseAthletes I haven't given my kidneys a second thought until now. It's easy to take care of your kidneys as long as you start early enough. Today on episode 125, Glen and I are speaking with the amazing Rick Johnson MD about all things kidney and more. This is Dr Johnson's third time on the show...this time to drill down into how to keep our kidneys healthy (and a little bit about avoid Alzheimers). Declining kidney function is a normal feature of aging...perhaps it is a driver of agings. I am trying to age as slowly as possible, which means I must keep my kidneys healthy. Are you taking care of your kidneys? Do you even know how to take care of your kidneys? Do your blood tests show a dropping eGFR year after year? Is your blood pressure going up as you get older? Do you ever get dehydrated? Do you ever take ibuprofen? This episode is for you Take care of your kidneys so they can take care of you! Dr. Richard Johnson is a practicing physician and clinical scientist and a world expert on sugar, and especially fructose, and its role in health. His research has been largely supported by the National Institutes of Health (NIH). He is one of the most cited scientists in his field and has published more than 750 papers and lectured in over 45 countries. He has authored three books on sugar and its health effects--The Sugar Fix with Timothy Gower in 2008; The Fat Switch in 2012, and Nature Wants Us to Be Fat (2022) in which Dr Johnson details his group's discovery of a switch that controls obesity and how it can be turned on and off. He is currently Professor of Medicine at the University of Colorado in Denver. He lives in Aurora, Colorado with his wife, Olga, children, Tracy and Ricky, and two goldendoodles, Charlie Brown and Apollo 11. For more information, visit www.drrichardjohnson.com Bullet points What causes kidney disease? High sugar diets / Metabolic syndrome / Diabetes (cut back on sugar in food)Gout / High Uric acid: stay hydrated, avoid fructose (sugar is ½ fructose), minimize the purines (beer, shellfish, sardines, processed meats, gravy, bacon), take vit C (500 mg / day), quercetin, certain diuretics, SGLT2 inhibitors lower uric acid"Aging" (may be related to high sugar or high carbohydrate diets)High blood pressureNSAIDs (ibuprofen is bad for kidneys; aspirin and Tylenol are okay)Proton Pump Inhibitors (PPI)Dehydration (drink 8-10 glasses of water every day, and drink before consuming salty foods). Don't drink too much too fast, especially after getting behind (being dehydrated).Spikes in blood sodium leads to temporary increases in BP which can progressively develop damage in the kidneys. Fat is a storage of calories and a source of water (metabolic water)Mild dehydration (can be from eating salty food) causes the body to want to accumulate fat (makes you hungry); but drinking water eliminates this effect. Drink 8-10 glasses of water per day.Dehydration Test: (1) urine color in the bowl mixed with the toilet water should be clear or just slightly yellow, (2) low specific gravity of urine (A sign of kidney disease is have to pee more often but not as much volume...having to get up more

Pain is a terrible word. Four little letters that I used to believe mean I can't or I'm broken or worse. But, today on episode 124, I speak with Ryan Whited and Matt Fitzgerald, co-authors of Pain and Performance, to hear the origin story behind "Training as Treatment" and the 3-step process that we all can use to get on the path to better performance and less downtime and less hassle with pain solutions that don't work. While pain is communication, it does not mean "injury" or "imbalance" or "wear and tear"...and we can be more self sufficient in managing pain. Pain and Performance on Amazon Related info and other Matt Fitzgerald episodes: Paragon AthleticsPain and Performance on AmazonEpisode 82 -- Mind Over Muscle w/Matt FitzgeraldEpisode 76 - Body Comp w/Matt Fitzgerald Some of the many Wise Athletes episodes about Pain Episode 92 - Knee Magic w/Ebonie RioEpisode 83 - PainScience w/Paul IngrahamEpisode 73 - End to Pain w/Rick Olderman PTEpisode 52 - Make Your Joints Last w/Howard Luks MDEpisode 14 - Pain is Not What You Think w/Charlie Merrill PT Want to support the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES Thanks.

25% or Higher Savings on Supplements for WiseAthletes This isn’t the sort of topic I usually cover on the Wise Athletes podcast but it should be.  Enjoy my talk with Lauren Hurst, author of North of Forty. In North of Forty, senior fitness expert Lauren Hurst and photographer Nick Cinea tell the stories of over 50 senior athletes ranging from ages 54 to 103, marathoners to martial artists to mountaineers, ordinary and extraordinary people. Told through captivating interviews and illustrated by stunning black and white portraits, their stories will inspire anyone who's made it "north of forty" and kept climbing. https://www.northfortyfitness.com/

I often say I don't want to LIVE forever, I just don't want to stop having fun. Today on episode 122 I am speaking with Bill Gifford, the author of “Spring Chicken: Stay Young Forever (Or Die Trying)” and the co-author of the recent best-seller "Outlive: The Science and Art of Longevity" written with Peter Attia MD. Bill wrote Spring Chicken back in 2015 when he was just beginning on his exploration of healthspan and longevity, and used his journalistic skills to share his findings with us all. And more recently, Bill worked with Peter Attia to write the latest longevity blockbuster with the latest, best scientific knowledge about how each of us can slow the rate of aging ...and keep having fun for a long, long time. Spring Chicken is a super fun read and a rip-roaring journey into the world of anti-aging science - a murky place filled with extraordinary breakthroughs (new) and dangerous deceptions (new and old). Bill Gifford is a journalist comfortable writing for periodicals on lifestyles and health, who has the chops to tackle an in-depth look at the complexities surrounding aging and what we can (and can't) do about it. Gifford leaps deftly into the fray, sifting through both the nonsense and the sensible, all while learning some things about his own aging body along the way. Gifford’s analysis takes into account the fact that the concept of old age has changed over the millennia, with life expectancy expanding, meaning more old people are alive now than ever before. Unfortunately, with longer lives has come the increased need for a daily medication of some sort, and heart disease, cancer, diabetes and Alzheimer’s disease are acting as the inevitable escorts down the last stretch to the pearly gates. Bullet points Don't be weak in any area of health...sometimes you have to do what you don't want to doYou don't have to make health a full time jobDon't focus on exercise. Instead find something fun to do that moves your bodyLongevity medicine has come a long way. Be safe when you venture off the map Related info and episodes: Outlive on AmazonSpring Chicken on AmazonEpisode 109 - Physical IntelligenceEpisode 115 -- Winning the Longevity Game More Bill Gifford info: Twitter (X): @billgifford Want to support the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES Thanks.

I just re-listened to this episode from 3 years ago with Charlie Merrill, PT as a part of my preparation for another amazing episode I will publish very soon. I was stunned at how great this episode was. It is no wonder that this chat with Charlie is the #1 episode of all time on the Wise Athletes podcast. Do yourself a favor....listen to Charlie. Original Show Notes from Episode #14, January 2021 Today, Glen and I are joined by Charlie Merrill, PT in Boulder, Colorado. Charlie is a Physical Therapist who has been serving the Boulder community and athletes for over 20 years.  Over the past few years, Charlie has added pain science and more psychologically informed modalities to his manual therapy and biomechanical toolkits. He emphasizes the body and mind in identifying physical AND psychological/social factors that result in physical symptoms, like pain.  Charlie says the source of most athlete’s pain is often not what you’d expect and you can now work with him remotely at Lin Health, a new pain management platform.   Charlie's website is Mperformance.com Charlie's new pain management platform: https://www.lin.health/ Charlie's Youtube channel has nearly 200 videos with free content: https://www.youtube.com/channel/UCinoyk46RyzA1v6PqbUl8_w Charlie's and Dr Howard Schubiner's upcoming professional training for clinicians: https://adlpages.lpages.co/beyond-pain-education-registration/ I learned from Charlie that there is a disconnect between pain and structural damage in the body.  What regular people think is true is that pain indicates something wrong, something damaged...that pain is a signal to slow down, be careful, let the damage heal.  But that is not always true.  Pain comes from the brain. Listen in as Charlie explains the science and practice of solving pain issues for athletes. Some topics we touch on: What is pain and where does it come from? Is pain the same as damage to the body?What is pain that seems to come out of nowhere?What is chronic pain? Is it caused by damage to the body?Are overuse injuries real? Is Wear and Tear for athletes a thing?How to tell and how to deal with pain that is not related to damage in the body? Advice for the older athlete who wants to remain strong and active for a long time? (Hint: add fun, pursue novelty, connect with your psychology) The twin peaks model I referenced from the book "Explain Pain"Which can be downloaded here.  It's excellent for anyone to read: https://www.noigroup.com/product/explain-pain-second-edn-epub/ Other Resources: Wise Athletes Recovery Deep Dive

25% or Higher Savings on Supplements for WiseAthletes As we kick off the new year in 2024, I continue my pursuit of better stress management with one of the legends in the space. Today on episode 121, Glen and I speak with the great Brian MacKenzie...a best-selling author and recognized expert on stress adaptation…to help me to better understand how to rebalance my ability to perform well under stress and recover quickly to create greater performance longevity.    Brian explains his practice of stress adaptation to improve performance AND the quality of life. Brian says we have to see what we really want so that we will be willing to do what it takes create sustainable performance. Higher HRV is not enough; know your why to have the motivation and staying power needed to make it happen. And, if you do it right, you'll get higher HRV. Brian is the Founder & CEO of Shift. He is also the President and Co-Founder of The Health and Human Performance Foundation, a non-profit organization dedicated to researching how breath and innate tools can optimize and help health and human performance.  Brian has also co-authored the book Power Speed Endurance, The New York Times Best Seller UnBreakable Runner, and UnPlugged. And, Brian is the co-founder of The Art of Breath, a course he teaches through SH//FT that teaches a principles based approach to breath & performance. Bullet points Eagle Story -- Don't be an Eagle that lived like a ChickenDo more non-exercise movement: 10k steps a day, or 2 sessions of zone 1 cyclings a day (max 15 breaths per minute; nasal breathing)Build in cycles of up/down stress every day. Find time for recovery snacks: drive the speed limit, don't take the smartphone into the bathroom, breathing exercises several times a dayBreathing Gears: Gear one: 2 seconds inhale; 2 seconds exhale...nasal breathingGear two: power nasal breathing...fast inhale/exhale (only for 25 breaths before shifting to mouth breathing) Test CO2 tolerance to check your nervous system status. Then build a plan to recapture your ability to flex between stress and relaxation / recoveryBrian's Speed Power Endurance book: https://a.co/d/3LKSEQLPeter Crone YouTube channel: https://www.youtube.com/channel/UCcakm7T9YgnrWYL4g15DrgwErnest Rossi - Ultradian: https://www.ernestrossi.com/interviews/ultradia.htmAnthony De Mello -- Awareness book (I saw $6 used copies on Amazon) Related info and episodes: Brian MacKenzie websiteshiftadaptThe Health and Human Performance FoundationEpisode 68 - becoming-anti-fragile-w-dr-mike-t-nelson

It’s that time of year when my carefully manicured and effortless diet of healthy foods with just the right amount of calories is destroyed in an orgy of holiday indulgence.  But that’s okay, the trick is to get back on track quickly.  To help me I thought I would talk with an absolute expert, a true genius in helping to build a solid defense against the relentless whisperings of my more primal self…the emotional brain that worries about impending famine and the need for deep fat stores to survive the winter.    Today in episode 120 I talk with Dr Glenn Livingston, the author of Defeat Your Cravings, who has developed a program that gives us control while not making us feel deprived. It’s not a weigh loss program; it’s a how to stick with your plan program. So, enjoy your holiday celebrations, but be sure to listen in to make your New Year’s resolutions easier to keep.  Defeat Your Cravings....one-liners: Have a plan (or you are a part of someone else’s plan)Character beats willpower If you can form a craving, you can extinguish a craving; you are not powerlessFeeling aren’t factsDon’t try to put out the fire, build a fireplace around the fireMove your difficult food decisions from your impulses to your intellectAdd "crunch to your lunch""Hand over the chocolate and no one gets hurt""When you’re in a hole, stop digging". Always use the present moment to be healthy Aim with perfection (don't just try...do your best with every shot)Teach your brain that you are willing to endure any suffering in order to follow your own rulesOvereating and addiction are biological errors. Teach the brain where to get enough healthy foodAttitude, Judgement and Responses. These are the only things completely under your control. Embrace them. Use them.  The Process...a summary: Start with a simple rule. Don’t worry about losing weight at firstRaising the bar slowly but surelyPry yourself away from the inner craving at the moment of temptation. Use 7-11 breathing. Use your words. Count to tenDisempower the justifications of the inner craving to make the right decisions. Write them down; write down why it doesn’t make sense. Wait 24 hours before implementing a change to the food plan. Don’t believe that your happiness in life from eating your favorite indulgences will be lost forever. It isn’t true.  Reset your response to super stimuli Other:  stop eating highly processed foods (HPF), do food prep, create signals for ending eating at night Related info and episodes: Defeatyourcravings websiteGet a Free Copy of Defeat Your CravingsEpisode 45 - build-strong-habits-with-samuel-salzer Want to support the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique produ

HRV or heart rate variability has made a come-back in my pursuit of health, longevity, and athletic performance. Years ago I discarded HRV as one-less-thing-to-fuss-with, but I have been reborn as believer in the power of HRV to guide me in rebalancing my nervous system for the benefit of better stress management and better sleep. All thanks to Marco Altini, PhD Today on episode #119, I am speaking with the one and only Marco Altini, PhD. Marco says he is a scientist and developer mainly working at the intersection between health, technology and performance. He is also the founder of HRV4Training, which is trusted by more than 150 000 athletes, including olympic medalists and professional teams, to measure physiology and quantify stress, helping people of all ages and athletic pursuits to better balance training and lifestyle stressors.  In our discussion, Marco illuminates the many factors that impact the calculation of heart rate variability, how stress impacts the autonomic nervous system, and how we can use HRV as a biofeedback tool with deep breathing exercises to help us learn or re-learn how to self-regulate and better cope with stressful situations.  How to do HRV right: "Pick one good tool, be consistent in usage, be patient" Devices:  fingertip, ring, wrist, chest strap (only way to get actual HRV)Phone apps:  be sure to get proper error correction, and avoid conversion of standard algorithms to proprietary indexes Different algorithms …rMSSD is best but SDNN (used by Apple Watch) is fine. Skip the "readiness scores" and "indexes"Time of day:  all night sleep or upon wakeup (nothing is perfect; consistent is good enough)Body position: Sitting is best if done after wakeupBreathing method (for HRV baseline):  breath naturally, somewhere between "resonance" (6 bpm) and sleeping (12-20 bpm). Breath however you normally breath...nasal/mouth, and try not to breath more deeply than normalDo not over-breathe: if you blow off too much co2 it will increase stress; activate sympathetic ANS HRV biofeedback: "Rebalance the autonomic nervous system; build resilience and capacity to self-regulate & deal with life stress." Identify resonant frequency try 4.5-6.4 bpm. Inhale belly; exhale pursed lips. “Deep abdominal breathing following a pacing stimulus”. The apps will provide a sensory guide to time your inhale/exhale to match targeted frequencySynchronize breathing and heart rate. Maximize oscillations in heart rate that you see on the app2x/day for 20 minutes (work up to this...a few minutes before bed will have an impact)Continue for as long as you want to be healthy Related info and episodes: HRV4biofeedback.com/the-appHRV4TrainingCircadian Rhythms of the Autonomic Nervous SystemEpisode 107 - using-music-for-a-better-brain-body (relaxing after workouts)Episode 70 - healing-yourself-w-joe-taft (reference to meditation)

Intense exercise takes a biochemical toll. Research has shown that intense activity results in decreased levels of glutathione, our body’s homemade master antioxidant. And, that happens even when you start the day with enough glutathione despite the naturally declining levels found in the older athlete.  Without sufficient glutathione, the oxidative stress associated with exercise can reduce athletic performance and delay recovery.   Heck, low glutathione can make you look and feel old. Today we have invited Ross Pelton the Natural Pharmacist to educate us about Glutathione, the master antioxidant and a key biomarker of aging. Glutathione is made by the body to act as the master regulator of other antioxidants....when you have enough glutathione, your body can make or recycle all the antioxidants it needs. What's more, low glutathione is a marker for aging and a higher likelihood of disease. The older we get, the less glutathione our bodies make, and the more glutathione our bodies need.  Glutathione IV drips are all the rage these days, but do we need it? Ross is the Natural Pharmacist and his website, bio and blog are at naturalpharmacist.net. He is passionate about life extension and anti-aging science and technology. He has written 12 books including “Rapamycin, mTOR, Autophagy & Treating mTOR Syndrome” and in 1999, he was named one of the Top 50 Most Influential Pharmacists in the U.S. by American Druggist magazine The Critical Roles of Glutathione Direct chemical neutralization of singlet oxygen, hydroxyl radicals, and superoxide radicalsCofactor for several antioxidant enzymesRegeneration of vitamins C and ENeutralization of free radicals produced liver metabolism of chemical toxinsTransportation of mercury out of cells and the brainRegulation of cellular proliferation and apoptosis (think: cancer)Vital to mitochondrial function and maintenance of mitochondrial DNA (mtDNA) A few of the benefits an athlete can expect from glutathione. Improved Endurance and Performance -- Glutathione has been shown to improve physical exercise endurance and increase energyReduced Muscle Soreness and Inflammation -- Glutathione helps to rebuild damaged & tired muscles, so it can reduce the time in painEnhanced Recovery Time -- It’s easy to get stuck in a cycle of soreness. Reduce your recovery time to accelerate your training progressionEnergy Production -- Glutathione is vital to the body’s ability to create energy as it is a key ingredient in the function of ATP, which is used by our bodies to create energyImproved Immune System Function -- A healthy and efficient immune system is key to athletic performance. If you’re feeling unwell, your perform will suffer Considering how important glutathione is to health, researchers have looked for ways to increase intracellular and intramitochondrial levels. Here are the effective approaches: Decrease the need for glutathione, which means decreasing toxic load (e.g., limit alcohol). The most obvious is limiting alcohol consumption.  Less obvious is decreasing exposure to persistent organic pollutants, the primary source of which are conventionally grown foods.  Another strategy is to provide other antioxidants to decrease oxidative stress. A good example is α-lipoic acid, supplementation of which increases mitochondrial glutathione levels even though ALA is not used in the synthesis or recycling of glutathione.Consuming glutathione does not work, but we can provide specific nutrients to promote glutathione production. Cysteine availability is the rate-limiting step in the de novo production of glutathio

For centuries the search for eternal youth or elongated life has been a frequent topic of various myths and legends from around the world.  Adventurers looked in far away lands for clues to the healing waters. In modern times, pharmaceutical companies hunted in jungles and tropical islands for exotic molecules that could be used to solve human disease. Now Ora Biomedical is searching among chemicals and combinations of chemicals laying in plain sight for clues to massive life (and health) extension. And now you can participate by sponsoring a compound that you know or just think is worth $100 to take a look. Today we are talking with Mitchell Lee, PhD about Ora Biomedical's Million Molecule Challenge and its new citizen science fundraising approach that allows everyone to participate in completing the moonshot Million-Molecule Challenge (assess 1,000,000 longevity interventions in 5 years vs. just under 1,100 compounds tested so far by modern science). In addition, Dr Lee and I discuss my question of how to be "bold but safe" regarding the high-wire act of using off-label pharmaceuticals and OTC nutritional supplements to get a fast start (i.e., start now) on the pursuit of extended human healthspan. This question has been burning my brain as I personally search for a path that avoids the slippery slope of wishful thinking, marketing overpromises (lies) and the dangers of combining too many powerful chemicals. From Ora Biomedical's website: "...from a small pilot screen of a few mTOR inhibitors, Ora has already identified one that works better than rapamycin....our preliminary data lead us to believe that combinations of 2-5 different longevity interventions have the potential to be twice to ten times as effective as the current best-in-class." Related episodes: Episode 95: The Next Rapamycin w/Dr Mitchell LeeEpisode 115: Being Bold & Safe w/Dr Rick Cohen & Daniel Tawfik More Ora Biomedical Info: Ora Biomedical websiteorabiomedical.com/sponsor-mmc/youtube.com/watch?v=kEzRU_jTKl8Dr Lee on X, formerly known as Twitter @michellblee33 Want to support the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES Thanks. Dr Mitchell Lee Bio Dr Lee received his PhD in Experimental Pathology from the University of Washington School of Medicine, where he trained with Matt Kaeberlein . He is the Co-founder and CEO of Ora Biomedical, a new pharmaceutical company seeking to realize the full potential of healthy aging therapeutics by developing "a new generation of broad use

...it's a fool's errand to try and make older people young. But it's enormously fun to try and make older people fast. That's fun. And it's very good for you, almost certainly. And, do the work; shortcuts tend not to turn out very well or for very long in older athletes. The better cyclist you want to be past 50, the more you probably have to drop cycling sessions out and put something else in to compensate. So you probably need to drop a cycling session now and put in a gym session, or a running session, or some other sport to work on bone density and muscle fibre loss. So it's a counterintuitive thing. The more you cycle and the more you seek cycling performance, the more you probably need to cast your net a bit wider. Sometimes you need to slow down to go fast. Phil Cavell is the author of The Midlife Cyclist', a book for the 40+-year-old cyclists who want to train hard, ride fast and stay healthy. It's less of a how-to and more of a philosophy of the older athlete...a collection thoughts and ramblings. It's what you’d talk about with a doctor friend who knew everything about the body and cycling the bike.  Phil says to stop by Cycle Fit to say hello if you are ever in London. I know I will. Links: Cycle Fit website: https://www.cyclefit.co.uk/Episode 88 - Strong Heart w/Dr Ben Levine: https://www.wiseathletes.com/podcast/88-how-to-get-a-strong-heart-for-performance-and-health-much-more-w-dr-ben-levine/Episode 63 - Boosting Testosterone: https://www.wiseathletes.com/podcast/63-boosting-testosterone-right-with-rick-cohen-md/Episode 32 - Metabolic Flexibility: https://www.wiseathletes.com/podcast/32-helping-older-athletes-feel-young-again-via-metabolic-and-physiologic-flexibility-with-dr-mike-t-nelson/ Phil Cavell Bio: Phil Cavell is the CEO of the London-based bike fitting studio, Cycle Fit. As well as being an expert on the biomechanics of cycling, Phil has recently written 'The Midlife Cyclist', a book for the 40+-year-old cyclists who want to train hard, ride fast and stay healthy. Want to help the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES Thanks. Detailed Show Notes Go slow to go fastDo less cycling to get better at cyclingDo the work; don’t resort to shortcuts which always backfire in the endSleep is the key to health and performance; work it out and never give up (or resort to drugs)Video yourself in action; see your disfunctionBe careful of alcohol and hard exercise for the older athlete heart

A healthy athlete is a strong athlete, and athletic longevity requires a long life. To achieve our athletic longevity goals, almost all of us resort to the optimistic usage of pills and powders. One of the major bummers for the older athlete, is that no one knows how to make people younger.  All we can do is slow down the rate of aging.  The healthier we are, the slower we age….meaning the more slowly we progress toward that visit to the pearly gates.  How can we balance risk and reward, prioritize which interventions to pursue first, how to tell is we are getting a positive or negative result from our interventions including pharmaceuticals and nutritional supplements. These are the questions answered by Daniel and Rick, who also share their thoughts about Rapamycin dosing, cycling interventions to restore beneficial cycles of growth and autophagy, and how Healthspan is delivering a platform to help clients to set proper goals and stay on course over time including taking corrective action when interventions (type and dose) don't deliver results. Links: Healthspan Longevity Medicine website: https://www.gethealthspan.com/ Episode 96 - Healthspan Longevity Medicine: https://www.wiseathletes.com/podcast/96-what-is-longevity-medicine-w-daniel-tawfik-co-founder-of-healthspan/ Episode 63 - Boosting Testosterone: https://www.wiseathletes.com/podcast/63-boosting-testosterone-right-with-rick-cohen-md/ Dr Rick Cohen & Daniel Tawfik Bios: Dr. Rick Cohen, M.D. is a leading authority in the fields of nutrition, sports performance and longevity medicine. He received his undergraduate degree in Biomedical Engineering with honors of distinction from Duke University in Durham, North Carolina and his medical degree from Hahnemann Medical University in Philadelphia, Pennsylvania. Rick is also a leader in the field of male functional hormone health and the author of the book “Be All the Man You Can Be” with over 100k copies sold in the past five years.  Daniel Tawfik is the founder, developer, and CEO of HealthSpan. Daniel holds a BS degree from UCLA in molecular, cellular, and developmental biology and physics. Daniel did his graduate research at UCLA's Protein Expression Technology Center where he studied neurometabolic disorders. Want to help the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES Thanks. Detailed Show Notes Today we are talking about one particular aspect of acquiring and retaining healthiness:  the chemicals we put into our bodies.  Chemicals include:  pharmaceuticals, botanicals, herbs, spices, concentrated foods, vitamins, minerals.   Today, we are NOT going to talk about specific recommendations for specific chemicals…rather we are going to discuss how to think about using chemicals in a way that is safe and responsible, while also bein

Moringa is known as the miracle tree because of its many beneficial features, which include: it helps to increase the blood antioxidants and reduce the blood sugar as well as chronic inflammation. It provides 7 times more vitamin C than oranges, 10 times more vitamin A than carrots, 17 times more calcium than milk, 9 times more protein than yoghurt, 15 times more potassium than bananas, and 25 times more iron than spinach.  Rightly so it is on everybody’s superfood list because Moringa truly is a miracle tree. Links: KuliKuliFoods website: https://www.kulikulifoods.com/ (use discount code: wiseathletes)Episode 94 - Phytonutrients: https://wiseathletes.com/podcast/94-phytonutrients-the-1-that-makes-all-the-difference/Episode 100 - Phytonutrients Practical Tips: https://wiseathletes.com/podcast/100-practical-tips-for-phytonutrients-and-fiber-w-dr-jed-fahey/Dr Jed Fahey’s website Lisa's & Jed's Bios: While working with women farmers in Niger, Kuli Kuli’s founder Lisa Curtis was introduced to the energizing and healing powers of Moringa. Out of that experience, Lisa dreamed of a business that would help Americans experience the power of superfoods like Moringa while empowering female farmers around the world. Out of that dream, Kuli Kuli was born. Dr. Fahey is THE INTERNET FAMOUS nutritional biochemist with extensive background in plant and human nutrition and phytochemistry. Want to help the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES Thanks.