In this episode Professor Steve Graham talks to Professor Mark Cotton, Department of Paediatrics and Child Health, Stellenbosch University. They discuss his early medical career, as the first paediatric infectious disease specialist in South Africa and one of the first doctors in Africa to treat children with antiretrovirals (ARVs), leading the Children with HIV Early Antiretroviral Therapy (CHER) trial, and current involvement in TB and HIV vaccine trials at Family Centre for Research with Ubuntu (FAMCRU). -- Professor Mark Cotton’s research has focussed on HIV and TB in children. Prof Cotton obtained his undergraduate degree in Medicine from the University of Cape Town; Master’s from the University of the Witwatersrand; and PhD in Immunology from Stellenbosch University. He interned at Groote Schuur Hospital and completed his postgraduate paediatrics training at various South African health facilities. After a Fellowship in Paediatric Infectious Diseases at the University of Colorado, he returned to South Africa to establish the Children’s Infectious Diseases Clinical Research Unit (KIDCRU). He is an Emeritus Professor at Stellenbosch University and advises World Health Organization on HIV in children. He has published/co-published more than 390 peer-reviewed articles in journals such as Lancet and the New England Journal of Medicine. He served on various editorial boards and was president of the World Society of Paediatric Infectious Diseases between 2019 and 2022. He now chairs its Education Committee.

In this episode Professor Steve Graham discusses bridging the knowledge-practice gap in tuberculosis management with Dr Trisasi Lestari, Universitas Gadjah Mada, Indonesia, and Dr Bazarragchaa Tsogt, Mongolian Anti-Tuberculosis Coalition, Mongolia. Dr Trisasi Lestari is a tuberculosis (TB) researcher at the Center for Tropical Medicine at the University of Gadjah Mada, Indonesia. Dr Lestari is also a PhD candidate at Menzies School of Health Research at Charles Darwin University. Dr Bazarragchaa Tsogt, Mongolian Anti-Tuberculosis Coalition. Professor Steve Graham is a Co-Chair for Melbourne Children's Global Health, Professor of International Child Health, University of Melbourne and Group Leader, International Child Health, Murdoch Children's Research Institute.   Further reading: du Preez K, Gabardo BMA, Kabra SK, Triasih R, Lestari T, Kal M, Tsogt B, Dorj G, Purev E, Nguyen TA, et al. Priority Activities in Child and Adolescent Tuberculosis to Close the Policy-Practice Gap in Low- and Middle-Income Countries. Pathogens. 2022; 11(2):196. https://doi.org/10.3390/pathogens11020196Lestari T, Kamaludin, Lowbridge C, Kenangalem E, Poespoprodjo JR, Graham SM, Ralph AP. Impacts of tuberculosis services strengthening and the COVID-19 pandemic on case detection and treatment outcomes in Mimika District, Papua, Indonesia: 2014-2021. PLOS Glob Public Health. 2022 Sep 30;2(9):e0001114. doi: 10.1371/journal.pgph.0001114. PMID: 36962674; PMCID: PMC10021881.Main S, Lestari T, Triasih R, Chan G, Davidson L, Majumdar S, Santoso D, Phung S, Laukkala J, Graham S, du Cros P, Ralph A. Training for Tuberculosis Elimination in Indonesia: Achievements, Reflections, and Potential for Impact. Trop Med Infect Dis. 2019 Jul 18;4(3):107. doi: 10.3390/tropicalmed4030107. PMID: 31323840; PMCID: PMC6789479.Lestari T, Graham S, van den Boogard C, Triasih R, Poespoprodjo JR, Ubra RR, Kenangalem E, Mahendradhata Y, Anstey NM, Bailie RS, Ralph AP. Bridging the knowledge-practice gap in tuberculosis contact management in a high-burden setting: a mixed-methods protocol for a multicenter health system strengthening study. Implement Sci. 2019 Mar 19;14(1):31. doi: 10.1186/s13012-019-0870-x. PMID: 30890160; PMCID: PMC6425655. South A, Dhesi P, Tweed CD, Tsogt B, Staples S, Tukvadze N, Dorj G, Zaca S, Sanikidze E, Purev N, Esmail H, Burgess R. Patients' priorities around drug-resistant tuberculosis treatment: A multi-national qualitative study from Mongolia, South Africa and Georgia. Glob Public Health. 2023 Jan;18(1):2234450. doi: 10.1080/17441692.2023.2234450. PMID: 37431789. Nunn AJ, Phillips PPJ, Meredith SK, Chiang CY, Conradie F, Dalai D, van Deun A, Dat PT, Lan N, Master I, Mebrahtu T, Meressa D, Moodliar R, Ngubane N, Sanders K, Squire SB, Torrea G, Tsogt B, Rusen ID; STREAM Study Collaborators. A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis. N Engl J Med. 2019 Mar 28;380(13):1201-1213. doi: 10.1056/NEJMoa1811867. Epub 2019 Mar 13. PMID: 30865791.Goodall RL, Meredith SK, Nunn AJ, Bayissa A, Bhatnagar AK, Bronson G, Chiang CY, Conradie F, Gurumurthy M, Kirenga B, Kiria N, Meressa D, Moodliar R, Narendran G, Ngubane N, Rassool M, Sanders K, Solanki R, Squire SB, Torrea G, Tsogt B, Tudor E, Van Deun A, Rusen ID; STREAM study collaborators. Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial. Lancet. 2022 Nov 26;400(10366):1858-1868. doi: 10.1016/S0140-6736(22)02078-5. Epub 2022 Nov 8. Erratum in: Lancet. 2022 Nov 19;400(10365):1766. PMID: 36368336; PMCID: PMC7614824.

In this episode, Sarah Andersson the World Scabies Program Manager talks to Oliver Sokana from the Solomon Islands Ministry of Health and Medical Services about the collaboration to eliminate scabies in Solomon Islands.  The World Scabies Program (WSP) is an initiative of Murdoch Children's Research Institute (MCRI). WSP was established in 2019 to support countries to implement health programs to reduce scabies. WSP builds on MCRI's experience in researching public health strategies for scabies and Solomon Islands Ministry of Health and Medical Services.    View or download the Transcript   Visit our website for more information and Join the conversation via social media

Description In this episode Professor Julie Bines and Professor Jarir At Thobari talk about the rotavirus vaccine research collaboration, the power of collaboration with a focus on the partnership between researchers in Indonesia and Australia, and how this collaboration will facilitate access to the RV3  rotavirus vaccine globally.  Professor Julie Bines is the Victor and Loti Smorgon Professor in the Department of Paediatrics at the University of Melbourne. She is a paediatric gastroenterologist and Head of Clinical Nutrition and Intestinal Rehabilitation at the Royal Children's Hospital in Melbourne, Australia. She leads the Enteric Diseases Group and the RV3 Rotavirus Vaccine Program at the Murdoch Children's Research Institute.  Professor Jarir At Thobari is a medical doctor at the Department of Pharmacology and Therapy and the Director of the Clinical Epidemiology and Biostatistics Unit in the Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada.     View or Download the Transcript   For more about their work visit:  Professor Julie Bines  Professor Jarir At Thobari    Visit our website for more information and Join the conversation via social media