The Dynasty DNA Fantasy Football Podcast offers advice for fantasy football dynasty leagues. When people start playing fantasy football, they usually join a redraft league. In this type of league, each team drafts all new players. In a dynasty league, each team instead carries over their players from the previous year.

Fantasy football players need to use different strategies in dynasty leagues. Dynasty DNA analyzes fantasy football from this different perspective. Host TJ Blake has been playing fantasy football for over fifteen years. Cohost Ty Blake enjoys all things fantasy, from redraft to dynasty. Cohost and weekly topic creator Andy Blake likes breaking down tape. Cohost and stat expert Ryan Mahle participates in over 20 dynasty leagues.

NFL rookies have great importance in dynasty fantasy football leagues. A star rookie player can become part of a dynasty fantasy football team for several years. The podcast hosts conduct rookie mock drafts on the show. In one episode, they combined the NFL draft classes of 2022 and 2023. They then conducted a rookie mock draft spanning both years. During the NFL preseason, the podcast hosts pay close attention to rookies. They identify some rookies as sleepers and some as busts.

The podcast hosts create rankings that redraft fantasy football players will recognize. They have a quarterback buys episode, a running back buys episode, a wide receiver buys episode, and a tight end buys episode. They also discuss ADP (average draft position). Other episodes include previews of all eight NFL divisions. Fantasy football players need to pay attention to how the professional teams perform.

The Dynasty DNA Fantasy Football Podcast premieres new episodes a couple of times a week during the regular NFL season. They continue to produce new episodes every week or so during the offseason.