The title of Geek's Guide to the Galaxy - A Science Fiction Podcast explains the concept. David Barr Kirtley hosts this podcast about science fiction and fantasy media. He talks to different guests about science fiction and fantasy media. David has interviewed authors like George R. R. Martin and Neil Gaiman on the show. He's also talked to scientists like Bill Nye and Neil deGrasse Tyson. Sometimes his guests are people in the movie industry.

John Joseph Adams is a guest on an episode about Dungeons & Dragons: Honor Among Thieves. He produced the movie, and writers Michael Witwer and Ben Riggs also join David. The men discuss past adaptations of Dungeons & Dragons, the famous role-playing game franchise. Michael's love of the game goes back to the 1980s Saturday morning cartoon show. He reminisces about some action figures he had. For some reason, there were no action figures of the main cast—only secondary characters.

Reflecting on the media through the lens of privileged childhood is a common theme. In one episode, a group of writers joins David to discuss movies from the 1970s. At the end of the episode, David asks Andrea Kail for her final thoughts. She notes that while there was some representation, there were also sexist stereotypes. David interrupts Andrea to remind her about the grouchy female scientist character in The Andromeda Strain. He continues to laud how Michael Crichton often used this character archetype.

David talks to writer Bill Fawcett about his friend and mentor, Robert Asprin. In this episode, they discuss the fun and challenges of writing chosen-path adventures. In these books, the reader can pick alternate outcomes at select points in the story.

Geek's Guide to the Galaxy - A Science Fiction Podcast is for people who like to discuss this genre. But one doesn't have to be a sci-fi fan to like the series.