Lead: Rapid Initiation of Injection Naltrexone for Opioid Use Disorder

This Week in Addiction Medicine from ASAM

May 28 2024 • 5 mins

Rapid Initiation of Injection Naltrexone for Opioid Use Disorder

JAMA Network

Standard initiation procedures (SP) for extended-release (XR)-naltrexone can be a barrier to initiation for patients. In this stepped-wedge cluster-randomized trial, they compared SP initiation (3-5 days buprenorphine taper, 7-10 days opioid-free) to a rapid procedure (RP) initiation (1 day buprenorphine, 1 day opioid free, 3-4 days ascending dose of oral naltrexone). Patients in the RP group (62.7%) were more likely to receive the initial XR-naltrexone dose (OR 3.6, P<0.001) than the SP group (35.8%). There was not a statistically significant difference between the groups in rate of 2nd and 3rd doses. The study demonstrates that RP for initiation of XR-naltrexone is non-inferior to SP and may lead to shorter in-patient stay.

Read this issue of the ASAM Weekly

Subscribe to the ASAM Weekly

Visit ASAM

You Might Like

8 Hour Sleep Music
8 Hour Sleep Music
8 Hour Sleep Music
Huberman Lab
Huberman Lab
Scicomm Media
Relaxing White Noise
Relaxing White Noise
Relaxing White Noise, LLC
White Noise and Sleep Sounds (12 Hours)
White Noise and Sleep Sounds (12 Hours)
White Noise and Sleep Sounds (12 Hours) to Sleep | Study | Relax | Soothe a Baby
Meditation Sounds
Meditation Sounds
Meditation Sounds
Guided Sleep Meditation & Sleep Hypnosis from Sleep Cove
Guided Sleep Meditation & Sleep Hypnosis from Sleep Cove
Sleep Hypnosis, Meditations and Bedtime Stories
Sleep With Me
Sleep With Me
Silver Sleeper Productions LLC
Mind Pump: Raw Fitness Truth
Mind Pump: Raw Fitness Truth
Sal Di Stefano, Adam Schafer, Justin Andrews, Doug Egge
Brown Noise Sleep Sounds
Brown Noise Sleep Sounds
Brown Noise Sleep Sounds