Mouse models, based on dietary, chemical or genetic interventions, are designed to serve as tools to understand human liver diseases.

With the number of models increasing:

• What types of models exist for hepatocellular carcinoma?
• How close do they mirror human liver cancer (subtypes)?
• Can they be used to predict therapeutic response?
• What are the best models? For which questions?
• From idea to conception, are we getting lost in translation?

Read this recent Journal of Hepatology article, on which the discussion was based.

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