This episode focuses on treatment options for intermediate-risk pulmonary emboli (PE). We define the intermediate-risk (or submassive )PE and controversies surrounding its detection including imaging and laboratory evaluation. Evidence suggests that it is not only the PE that makes it intermediate risk but also the kind of patient that we find the PE in. Most of our time in the episode we discuss therapies, specifically thrombolytics, and the evidence and controversy behind their use in this entity.