Thick Threads explores the weirdest, funniest, and most outrageous corners of the internet. The podcast hosts research social media and message boards to find wild stories. Persephanii and Patrick Cloud, or just Cloud, bring anonymous tales of people confessing online. Some divulge their antics on crazy nights out. Others reveal how they discovered their partner was cheating on them. There are recounts of sex parties, crimes, and stalking. Persephanii and Cloud read out these posts and share their opinions. The hosts also talk about similar anecdotes from their lives and make jokes along the way. It's a lighthearted conversation that uncovers life's most exciting experiences.

The Thick Threads podcast hosts are both notable internet personalities. Persephanii has a successful YouTube channel with hundreds of thousands of subscribers. She uploads fashion videos, vlogs, and skits. Her Instagram, where she showcases her modeling talent, has over 1 million followers. Her cohost, Cloud, is a producer, musician, and director. Cloud helped create three different YouTube channels. Those include All Def Digital, All Def Gaming, and Gaming While Black. He also has a personal channel that showcases funny animals, reviews products, and shares gaming videos.

Both hosts of Thick Threads have an extensive understanding of the online world. They know all the latest social media trends, memes, and most viewed videos. This experience helps Persephanii and Cloud to create funny content around online conversations.

The topics on Thick Threads are a mixture of wholesome, raunchy, and horrifying. Persephanii shares a thread about little gifts that can brighten a person's day. Cloud reveals a story about a person having amorous encounters with strangers on the subway. There are also tales of ghosts and spies. The conversations often become weirder than the hosts expected. But thanks to their witty banter, they ensure the podcast content remains amusing.