Neighborhood Health in Alexandra, VA, is in a race to protect the underserved and the unvaccinated against the Delta variant of COVID-19. In our second episode, Executive Director and clinician Basim Khan, MD, describes how the ground game against COVID has changed. Their strategy has shifted from operating mass vaccination sites to engaging hard to reach populations where they are and partnering with trusted messengers, such as faith leaders and community organizations, to build confidence in the COVID vaccine and counter misinformation.