The Mike Missanelli Podcast features the veteran Philadelphia sports personality. Mike Missanelli began his career writing for The Philadelphia Inquirer. He went on to host the midday show on ESPN Radio's Philadelphia affiliate 97.5 The Fanatic for twelve years.

Missanelli had great timing when he started The Mike Missanelli Podcast. The show debuted in September 2022. The Phillies went to the World Series the very next month. In February 2023, the Eagles went to the Super Bowl. Unfortunately for Philly fans, both teams lost. There continues to be plenty of local sports drama for Missanelli to discuss.

The host often has guests on his show. Many of these guests are local beat writers from Missanelli's earlier stops. Inquirer beat reporters Scott Lauber and Keith Pompey have appeared on the podcast. Lauber covers the Phillies and Pompey covers the NBA 76ers. ESPN Eagles beat reporter Tim McManus has also appeared on the podcast to talk Eagles.

Missanelli has interviewed Peter King on the podcast. The longtime sports columnist's 2023 preseason pick to win the Super Bowl was the Eagles. Flyers general manager Danny Briere has also appeared on The Mike Missanelli Podcast. Other guests have been former Sixers coach Larry Brown and former Eagles player Seth Joyner. When the Phillies made the 2022 World Series, former Phillies shortstop Larry Bowa appeared on the podcast. Missanelli has also interviewed MLB Hall of Famer John Smoltz.

Missanelli does not limit his topics to sports. He offered his impressions of the Republican presidential debate. Missanelli talked about which candidates he might support. In 2023, he interviewed Josh Shapiro, the Democratic governor of Pennsylvania. Missanelli has also had comedian Nikki Glaser on the podcast. No matter what the topic, this Philly-focused podcast makes it interesting. The Mike Missanelli Podcast has new episodes twice a week.