Billy & Lisa in the Morning airs daily from 6 a.m. to 10 a.m. The Boston-based Kiss 108 show started its run in 2022. From the beginning, it was also available in podcast format. The podcast splits each day's show into three episodes. The two longer episodes are the main part of the show. That's where the two hosts share banter, discuss pop culture, and speak with guests. The shorter episodes contain the day's news from both Massachusetts and the rest of the US.

Billy Costa and Lisa Donovan joined the station's morning show to replace Matt Siegel. The then-host of Matty in the Morning decided to retire after 41 years to spend more time with his family. With his abrupt departure, Billy and Lisa acted as temporary replacements. When the show started to gain more listeners, the people in charge decided to make it official. The show received the name Billy & Lisa in the Morning. Justin Aguirre and Winnie Akoury also join as occasional cohosts. Listeners can follow all their morning action with this podcast.

Both hosts of the show and podcast are veterans when it comes to radio. Billy joined the Boston station in 1980. He hosts the weekly Top 30 Countdown and has worked on other aspects of the morning show for decades. He also presented on a local sports TV show called Dining Playbook. Lisa joined Kiss 108 and the morning show in 2002. Beforehand, she worked for ten years in public relations in NYC. As she collaborated with many lifestyle brands, she gained a lot of knowledge of pop culture.

Billy and Lisa have an on-air chemistry that's hard to deny. They always find something to laugh about, whether they're discussing the traffic, the weather, or Ariana Grande. Most Billy & Lisa in the Morning episodes focus on the entertainment industry. They discuss music, film, and TV stars, whether it's news or rumors. In between, there are some personal stories from the hosts, anecdotes, and a lot of wit. Episodes drop daily and include individual segments as well as longer episodes.