Eagle's Eye View: Your Weekly CV Update From ACC.org

American College of Cardiology

The weekly cardiovascular update from ACC.org Editor-in-Chief Kim Eagle, MD, MACC, covering the hottest cardiovascular topics, from new clinical guidelines to practice-changing research and innovative quality initiatives and tools. read less

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Mechanical Circulatory Support in Infarct-Related Cardiogenic Shock, Anticoagulation Benefit in Device-Detected AFib, Semaglutide in HFpEF Patients

Mechanical Circulatory Support in Infarct-Related Cardiogenic Shock, Anticoagulation Benefit in Device-Detected AFib, Semaglutide in HFpEF Patients

In this week’s View, Dr. Eagle looks at temporary mechanical circulatory support in infarct-related cardiogenic shock. He then explores the anticoagulation benefit in device-detected atrial fibrillation with or without vascular disease as reported in a combined analysis of the NOAH-AFNET 6 and ARTESiA trials. Finally, Dr. Eagle discusses a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomized trials that documented the effectiveness of semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction. Subscribe to Eagle’s Eye View

Episodes

Mechanical Circulatory Support in Infarct-Related Cardiogenic Shock, Anticoagulation Benefit in Device-Detected AFib, Semaglutide in HFpEF Patients

Mechanical Circulatory Support in Infarct-Related Cardiogenic Shock, Anticoagulation Benefit in Device-Detected AFib, Semaglutide in HFpEF Patients

In this week’s View, Dr. Eagle looks at temporary mechanical circulatory support in infarct-related cardiogenic shock. He then explores the anticoagulation benefit in device-detected atrial fibrillation with or without vascular disease as reported in a combined analysis of the NOAH-AFNET 6 and ARTESiA trials. Finally, Dr. Eagle discusses a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomized trials that documented the effectiveness of semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction. Subscribe to Eagle’s Eye View

SGLT2 Inhibitors vs. GLP-1 RAs in Diabetes, MRI Lesions After TAVR, Perioperative Management and Anticoagulants

SGLT2 Inhibitors vs. GLP-1 RAs in Diabetes, MRI Lesions After TAVR, Perioperative Management and Anticoagulants

In this week’s View, Dr. Eagle looks at the kidney and cardiovascular effectiveness of SGLT2 inhibitors versus GLP-1 receptor agonists in type 2 diabetes. He then explores the prognostic ability of diffusion-weighted brain MRI lesions after TAVR. Finally, Dr. Eagle discusses perioperative management of patients taking direct oral anticoagulants, particularly those being considered for noncardiac surgery. Subscribe to Eagle’s Eye View

Social Determinants of Health in Cardiology, Aortopathy in Children, Cardiac CT Following Left Atrial Appendage Occlusion

Social Determinants of Health in Cardiology, Aortopathy in Children, Cardiac CT Following Left Atrial Appendage Occlusion

In this week’s View, Dr. Eagle looks at the 2024 ACC/AHA key data elements and definitions for social determinants of health in cardiology. He then explores key points of management of aortopathy in children. Finally, Dr. Eagle discusses the recent position statement on the use of cardiac CT following left atrial appendage occlusion. Subscribe to Eagle’s Eye View

Genetics and Risk in Aortic Disease, Plant vs. Animal Fat in Cardiovascular Outcomes, Management of Cardiac Sarcoidosis

Genetics and Risk in Aortic Disease, Plant vs. Animal Fat in Cardiovascular Outcomes, Management of Cardiac Sarcoidosis

In this week’s View, Dr. Eagle looks at the potential role of genetics in predicting risk in people with aortic disease. He then compares plant and animal fat intake in overall cardiovascular disease outcomes. Finally, Dr. Eagle discusses a clinical consensus statement on the management of cardiac sarcoidosis from the European community. Subscribe to Eagle’s Eye View

Update to ACC/AHA Heart Failure Performance Measures; Quadruple Therapy and HF; ACEi, ARBs, and Chronic Kidney Disease

Update to ACC/AHA Heart Failure Performance Measures; Quadruple Therapy and HF; ACEi, ARBs, and Chronic Kidney Disease

In this week’s View, Dr. Eagle looks at the 2024 update to the 2020 ACC/AHA Clinical Performance and Quality Measures for Adults With Heart Failure (HF). He then explores the eligibility and projected benefits of rapid initiation of quadruple therapy for newly diagnosed HF. Finally, Dr. Eagle discusses a systematic review of clinical trials investigating the use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin-receptor blockers (ARBs) for advanced chronic kidney disease (CKD). Subscribe to Eagle’s Eye View

Pulmonary Hypertension and HF, Obesity in Adolescents, Noncardiac Surgery After TAVR

Pulmonary Hypertension and HF, Obesity in Adolescents, Noncardiac Surgery After TAVR

In this week’s View, Dr. Eagle looks at post-capillary pulmonary hypertension in heart failure and the revised European guideline definition. He then explores obesity in adolescents and its impact on our societal health. Finally, Dr. Eagle discusses a national analysis of the timing of noncardiac surgery following transcatheter aortic valve replacement (TAVR): is there an optimal time for surgery after TAVR? Subscribe to Eagle’s Eye View

Fenestrated-Branched Endovascular Aortic Repair, Mortality and PCI, Lp(a) and Calcific Aortic Stenosis Progression

Fenestrated-Branched Endovascular Aortic Repair, Mortality and PCI, Lp(a) and Calcific Aortic Stenosis Progression

In this week’s View, Dr. Eagle looks at a prospective multicenter cohort study that examined early and late aortic-related mortality and rupture after fenestrated-branched endovascular aortic repair of thoracoabdominal aortic aneurysms. He then explores periprocedural mortality in patients having PCI and a rise in biomarkers. Finally, Dr. Eagle discusses a systemic review and meta-analysis of lipoprotein(a) and calcific aortic valve stenosis progression. Subscribe to Eagle’s Eye View

Diuretics and HF, Implantable Cardioverter-Defibrillators and the Tricuspid Valve and Right Ventricle, Neurohormonal Blockade and HF

Diuretics and HF, Implantable Cardioverter-Defibrillators and the Tricuspid Valve and Right Ventricle, Neurohormonal Blockade and HF

In this week’s View, Dr. Eagle looks at a study comparing three diuretic regimens in ambulatory congested heart failure (HF) patients (DEA-HF). He then explores a randomized trial that investigates the effects of implantable cardioverter-defibrillator (ICD) leads on the tricuspid valve and right ventricle. Finally, Dr. Eagle discusses the effects of rapid up-titration of neurohormonal blockade in patients with acute decompensated HF. Subscribe to Eagle’s Eye View

Racial Differences in Diabetic Cardiomyopathy, Genetics of HCM, Semaglutide vs. Tirzepatide for Weight Loss

Racial Differences in Diabetic Cardiomyopathy, Genetics of HCM, Semaglutide vs. Tirzepatide for Weight Loss

In this week’s View, Dr. Eagle looks at the ARISE-HF trial that examined racial differences in diabetic cardiomyopathy. He then explores established and emerging implications of treatment of genetic hypertrophic cardiomyopathy (HCM). Finally, Dr. Eagle discusses the use of GLP-1 agonists, including semaglutide vs. tirzepatide for weight loss in adults with overweight or obesity. Subscribe to Eagle’s Eye View

Iron Repletion and Heart Failure, Ventricular Septal Defect and Acute Myocardial Infarction, Hemodynamic Assessment for HF

Iron Repletion and Heart Failure, Ventricular Septal Defect and Acute Myocardial Infarction, Hemodynamic Assessment for HF

In this week’s View, Dr. Eagle discusses a state-of-the-art review on iron repletion for patients with heart failure and iron deficiency. He then explores the diagnosis and management of ventricular septal defect complicating acute myocardial infarction. Finally, Dr. Eagle discusses practical guidance for hemodynamic assessment by right heart catheterization in management of heart failure. Subscribe to Eagle’s Eye View

Early Rhythm Control, Low-Dose Aspirin and Prevention, Autoimmune Diseases and Atherosclerosis

Early Rhythm Control, Low-Dose Aspirin and Prevention, Autoimmune Diseases and Atherosclerosis

In this week’s View, Dr. Eagle looks at the clinical impact of early rhythm control and healthy lifestyles in patients with atrial fibrillation, then explores the use of low-dose aspirin in the prevention of atherosclerotic cardiovascular disease. Finally, Dr. Eagle discusses the association of autoimmune diseases with coronary atherosclerosis and ischemic events. Subscribe to Eagle’s Eye View

In-office and At-Home Blood Pressure Measurement, Artificial Intelligence and Cardiovascular Care, Inflammatory Risk

In-office and At-Home Blood Pressure Measurement, Artificial Intelligence and Cardiovascular Care, Inflammatory Risk

In this week’s View, Dr. Eagle looks at office measurement vs. ambulatory blood pressure monitoring and its associations with mortality in patients with or without diabetes. Dr. Eagle then reviews two related articles: a report in JACC on Artificial Intelligence and cardiovascular care, and a recent article from The Lancet on inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease in which AI played an important role. Subscribe to Eagle’s Eye View

Severe Aortic Stenosis, Titration and Acute Heart Failure, Pacemakers After TAVR

Severe Aortic Stenosis, Titration and Acute Heart Failure, Pacemakers After TAVR

In this week’s View, Dr. Eagle looks at secular trends of incidence and outcomes in severe aortic stenosis. He then examines titration of medications after acute heart failure. Finally, Dr. Eagle shares some thoughts on an analysis from the PARTNER2-S3 registry on the predictors and five-year clinical outcomes of pacemakers after TAVR. Subscribe to Eagle’s Eye View

Excess Apolipoprotein-B and Cardiovascular Risk, Treating Pulmonary Arterial Hypertension, SGLT2i and CV Outcomes

Excess Apolipoprotein-B and Cardiovascular Risk, Treating Pulmonary Arterial Hypertension, SGLT2i and CV Outcomes

In this week’s View, Dr. Eagle looks at excess apolipoprotein-B and cardiovascular risk, then examines a recent meta-analysis on treating pulmonary arterial hypertension. Finally, Dr. Eagle shares some thoughts on a SMART-C collaborative meta-analysis of sodium-glucose cotransporter-2 inhibitors and major adverse cardiovascular outcomes. Subscribe to Eagle’s Eye View

Anticoagulation in Post-Operative AFib, Non-ST-Elevation Acute Coronary Syndromes, Arrhythmia-Induced Cardiomyopathy

Anticoagulation in Post-Operative AFib, Non-ST-Elevation Acute Coronary Syndromes, Arrhythmia-Induced Cardiomyopathy

In this week’s View, Dr. Eagle looks at anticoagulation for post-operative atrial fibrillation after isolated coronary artery bypass grafting. He then examines a meta-analysis of invasive vs. conservative management of non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting. Finally, Dr. Eagle shares some thoughts on JACC’s recent State of the Art Review of arrhythmia-induced cardiomyopathy. Subscribe to Eagle’s Eye View

Aortic Valve Calcification and Aortic Stenosis, Microvascular Resistance Reserve After PCI, Microvascular Injury Patterns

Aortic Valve Calcification and Aortic Stenosis, Microvascular Resistance Reserve After PCI, Microvascular Injury Patterns

In this week’s View, Dr. Eagle looks at the diagnostic value of aortic valve calcification levels in the assessment of low-gradient aortic stenosis. He then examines the prognostic value of microvascular resistance reserve after percutaneous coronary intervention in patients with myocardial infarction. Finally, Dr. Eagle shares some thoughts on clinical outcomes associated with various microvascular injury patterns identified by cardiac MRI after STEMI. Subscribe to Eagle’s Eye View

Transcatheter-Based Intervention and Tetralogy of Fallot, Small Left Ventricle and Atrial Fibrillation (Afib), Aspirin Free Treatment Post-PCI

Transcatheter-Based Intervention and Tetralogy of Fallot, Small Left Ventricle and Atrial Fibrillation (Afib), Aspirin Free Treatment Post-PCI

In this week’s View, Dr. Eagle looks at transcatheter-based intervention for tetraology of Fallot. He then examines how a small left ventricle in patients with atrial fibrillation is associated with increased cardiovascular risk. Finally, Dr. Eagle shares some thoughts on an aspirin-free strategy for immediate treatment following complex percutaneous coronary intervention. Subscribe to Eagle’s Eye View

Guideline for the Management of Lower Extremity Peripheral Artery Disease (PAD), Decongestion Strategies for Heart Failure, Lipoproteins and Triglycerides in Cardiovascular Prevention

Guideline for the Management of Lower Extremity Peripheral Artery Disease (PAD), Decongestion Strategies for Heart Failure, Lipoproteins and Triglycerides in Cardiovascular Prevention

In this week’s View, Dr. Eagle looks at the recently released guidelines for lower extremity peripheral arterial disease (PAD). He then examines a national community-based cohort study on contemporary decongestion strategies in patients hospitalized for heart failure. Finally, Dr. Eagle shares some thoughts on the implications of discordance among ApoB, non–high-density lipoprotein cholesterol and triglycerides for cardiovascular prevention. Subscribe to Eagle’s Eye View

Eagle’s Eye View: The New AHA/ACC Hypertrophic Cardiomyopathy Guideline, Smoking Cessation, Embolic Stroke

Eagle’s Eye View: The New AHA/ACC Hypertrophic Cardiomyopathy Guideline, Smoking Cessation, Embolic Stroke

In this week’s View, Dr. Eagle looks at the new AHA/ACC Hypertrophic Cardiomyopathy Guideline, then examines a randomized clinical trial that studied smoking cessation after initial treatment failure with varenicline or nicotine. Finally, Dr. Eagle shares some thoughts on a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging, and the European Heart Rhythm Association of the ESC on embolic strokes of an undetermined source. Subscribe to Eagle’s Eye View

Eagle’s Eye View: Pulsed Field Ablation and Pulmonary Vein Isolation, Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives, TAVR or SAVR and Severe Aortic Stenosis

Eagle’s Eye View: Pulsed Field Ablation and Pulmonary Vein Isolation, Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives, TAVR or SAVR and Severe Aortic Stenosis

In this week’s View, Dr. Eagle looks at the durability of pulmonary vein isolation using pulsed-field ablation, then examines genetic penetrance of dilated cardiomyopathy in genotype-positive relatives. Finally, Dr. Eagle shares some thoughts on reinterventions after CoreValve/Evolut TAVR or SAVR for treatment of severe aortic stenosis. Subscribe to Eagle’s Eye View